Filaggrin Antikörper (AA 998-1104)

Produktnummer ABIN6252502

Der Maus Monoklonal anti-Filaggrin Antikörper wird verwendet zum Nachweis von Filaggrin in Proben von Human. Er wurde validiert für IHC, WB, IF und FACS.

Kurzübersicht für Filaggrin Antikörper (AA 998-1104) (ABIN6252502)

Target: Filaggrin (FLG)

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser Filaggrin Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (IHC), Western Blotting (WB), Immunofluorescence (IF), Flow Cytometry (FACS)

Klon: FLG-1561

Produktdetails anti-Filaggrin Antikörper

Bindungsspezifität: AA 998-1104

Aufreinigung: Protein G affinity chromatography

Immunogen: Amino acids 998-1104 of human FLG were used as the immunogen for this Filaggrin antibody.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Flow Cytometry: 0.5-1 μg/10^6 cells in 0.1ml

IF: 1-2 μg/mL

IHC (FFPE): 0.5-1 μg/mL for 30 min at RT

Optimal dilution of the Filaggrin antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.2 mg/mL

Buffer: PBS with 0.1 mg/mL BSA and 0.05 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Aliquot and Store at -20C. Avoid freez-thaw cycles.

Details zu Filaggrin

Target: Filaggrin (FLG)

Andere Bezeichnung: Filaggrin

Hintergrund: Filaggrin (FLG) is an intermediate filament-associated protein that aggregates keratin intermediate filaments in mammalian epidermis. It is initially synthesized as a polyprotein precursor, profilaggrin (consisting of multiple Filaggrin units of 324 aa each), which is localized in keratohyalin granules, and is subsequently proteolytically processed into individual functional Filaggrin molecules. Active Filaggrin is present at a level of the epidermis where keratinocytes are in transition between the live nucleated granular layer and the anucleate cornified layer, suggesting that filaggrin aids in the terminal differentiation process by facilitating apoptotic machinery.

Gen-ID: 2312

UniProt: P20930

Pathways: Sensory Perception of Sound, Stem Cell Maintenance