FLI1 Antikörper (AA 107-216)
Kurzübersicht für FLI1 Antikörper (AA 107-216) (ABIN6252309)
Target
Alle FLI1 Antikörper anzeigenReaktivität
Wirt
Klonalität
Konjugat
Applikation
Klon
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Bindungsspezifität
- AA 107-216
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Aufreinigung
- Protein G affinity chromatography
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Immunogen
- Human partial recombinant protein (amino acids 107-216) was used as the immunogen for this FLI1 antibody.
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Isotyp
- IgG
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Applikationshinweise
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Western blot: 1-2 μg/m,l
Flow Cytometry: 0.5-1 μg/10^6 cells
IF: 1-2 μg/mL
The concentration stated for each application is a general starting point. Variations in protocols, secondaries and substrates may require the FLI1 antibody to be titered up or down for optimal performance. -
Beschränkungen
- Nur für Forschungszwecke einsetzbar
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Format
- Liquid
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Konzentration
- 0.2 mg/mL
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Buffer
- PBS with 0.1 mg/mL BSA and 0.05 % sodium azide
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Konservierungsmittel
- Sodium azide
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Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Lagerung
- -20 °C
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Informationen zur Lagerung
- Aliquot and Store at -20C. Avoid freez-thaw cycles.
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- FLI1 (Friend Leukemia Virus Integration 1 (FLI1))
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Andere Bezeichnung
- FLI1
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Hintergrund
- Friend leukemia integration 1 is a member of the ETS family of DNA binding transcription factors that is involved in cellular proliferation and tumorigenesis. Members of the Ets gene family share a highly conserved carboxy-terminal domain containing a sequence related to the SV40 large T antigen nuclear localization signal sequence. Approximately 90 % of Ewing's Sarcoma (EWS) / Primitive Neuroectodermal Tumors (PNET) have a specific translocation, t(11,22)(q24,q12), which results in fusion of EWS to Fli-1, and production of an EWS-Fli-1 fusion protein. Among normal tissues only endothelial cells and small lymphocytes express Fli-1. This protein is expressed in majority of vascular tumors including angiosarcomas, hemangioendotheliomas, hemangiomas, and Kaposi's Sarcomas. High sensitivity and specificity of Fli-1 equals to or exceeds that of the established vascular markers like CD31, CD34, and Factor VIII.
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Gen-ID
- 2313
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UniProt
- Q01543
Target
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