EZH2 Antikörper (AA 410-440)

Produktnummer ABIN6244310

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch EZH2 in WB und IHC (p). Er zeigt eine Reaktivität gegenüber Human und Maus und wurde in 4+ Publikationen erwähnt.

Kurzübersicht für EZH2 Antikörper (AA 410-440) (ABIN6244310)

Target: EZH2 (Enhancer of Zeste Homolog 2 (EZH2))

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser EZH2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Klon: RB2921

Produktdetails anti-EZH2 Antikörper

Bindungsspezifität: AA 410-440

Homologie: X, Pr

Aufreinigung: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This EZH2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from 410-440aa of human EZH2.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB: 1:1000. WB: 1:1000. IHC-P: 1:50~100. IHC-P: 1:50~100

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Haltbarkeit: 6 months

Referenzen für anti-EZH2 Antikörper (ABIN6244310)

Pan, Wang, Zhu, Xing, Cui, Li, Yu, Wang, Zhu, Ye, Wu, Wang, Lu: "STAT3 signaling drives EZH2 transcriptional activation and mediates poor prognosis in gastric cancer." in: Molecular cancer, Vol. 15, Issue 1, pp. 79, (2017) (PubMed).

Lin, Zheng, Tu, Wang, Liu, Lu, Xu, Yuan: "MicroRNA-144 suppresses tumorigenesis and tumor progression of astrocytoma by targeting EZH2." in: Human pathology, Vol. 46, Issue 7, pp. 971-80, (2015) (PubMed).

Eskander, Ji, Huynh, Wardeh, Randall, Hoang: "Inhibition of enhancer of zeste homolog 2 (EZH2) expression is associated with decreased tumor cell proliferation, migration, and invasion in endometrial cancer cell lines." in: International journal of gynecological cancer : official journal of the International Gynecological Cancer Society, Vol. 23, Issue 6, pp. 997-1005, (2014) (PubMed).

Zhou, Flesken-Nikitin, Corney, Wang, Goodrich, Roy-Burman, Nikitin: "Synergy of p53 and Rb deficiency in a conditional mouse model for metastatic prostate cancer." in: Cancer research, Vol. 66, Issue 16, pp. 7889-98, (2007) (PubMed).

Details zu EZH2

Target: EZH2 (Enhancer of Zeste Homolog 2 (EZH2))

Andere Bezeichnung: EZH2

Hintergrund: EZH2, SUZ12, and EED form a complex that methylates nucleosomal histone H3 at Lys27. EZH2 contains a SET domain, a signature motif for all known histone lysine methyltransferases except the H3-K79 methyltransferase DOT1, and is therefore likely to be the catalytic subunit. Consequently, EZH2 is thought to regulate gene expression by controlling chromatin structure. Several lines of evidence suggested a critical role for the EZH2 protein during normal and perturbed development of the hematopoietic and central nervous systems. The EZH2 protein has been shown to associate with the VAV1 protooncoprotein and with the XNP protein, the product of a gene associated with mental retardation. Additionally, due to mapping of EZH2 to the 7q35-q36 chromosomal region associated with myeloid disorders, this protein is suggested to participate in the genetic events triggering myeloid leukemia.

Molekulargewicht: 85363

NCBI Accession: NP_001190176, NP_001190177, NP_001190178, NP_004447, NP_694543

UniProt: Q15910

Pathways: Retinoic Acid Receptor Signaling Pathway, Regulation of Muscle Cell Differentiation