NDEL1 Antikörper (AA 178-213)

Produktnummer ABIN6244172

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch NDEL1 in WB. Er zeigt eine Reaktivität gegenüber Human und Maus.

Kurzübersicht für NDEL1 Antikörper (AA 178-213) (ABIN6244172)

Target: NDEL1 (NudE Nuclear Distribution E Homolog (A. Nidulans)-Like 1 (NDEL1))

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser NDEL1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Klon: RB50842

Produktdetails anti-NDEL1 Antikörper

Bindungsspezifität: AA 178-213

Homologie: C, Pr, Rb, Rat

Aufreinigung: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This NDEL1 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 178-213 amino acids from the Central region of human NDEL1.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: WB: 1:1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Haltbarkeit: 6 months

Details zu NDEL1

Target: NDEL1 (NudE Nuclear Distribution E Homolog (A. Nidulans)-Like 1 (NDEL1))

Andere Bezeichnung: NDEL1

Hintergrund: Required for organization of the cellular microtubule array and microtubule anchoring at the centrosome. May regulate microtubule organization at least in part by targeting the microtubule severing protein KATNA1 to the centrosome. Also positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus ends. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the centripetal motion of secretory vesicles and the coupling of the nucleus and centrosome. Also required during brain development for the migration of newly formed neurons from the ventricular/subventricular zone toward the cortical plate. Plays a role, together with DISC1, in the regulation of neurite outgrowth. Required for mitosis in some cell types but appears to be dispensible for mitosis in cortical neuronal progenitors, which instead requires NDE1. Facilitates the polymerization of neurofilaments from the individual subunits NEFH and NEFL.

Molekulargewicht: 38375

UniProt: Q9GZM8

Pathways: Regulation of Cell Size