FHIT Antikörper (AA 19-54)

Produktnummer ABIN6244170

Der Kaninchen Polyklonal Anti-FHIT-Antikörper wurde für WB validiert. Er ist geeignet, FHIT in Proben von Human zu detektieren.

Kurzübersicht für FHIT Antikörper (AA 19-54) (ABIN6244170)

Target: FHIT (Fragile Histidine Triad (FHIT))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser FHIT Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Klon: RB53956

Produktdetails anti-FHIT Antikörper

Bindungsspezifität: AA 19-54

Aufreinigung: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This FHIT antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between19-54 amino acids from human FHIT.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: WB: 1:2000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Haltbarkeit: 6 months

Details zu FHIT

Target: FHIT (Fragile Histidine Triad (FHIT))

Andere Bezeichnung: FHIT

Hintergrund: Cleaves P(1)-P(3)-bis(5'-adenosyl) triphosphate (Ap3A) to yield AMP and ADP. Can also hydrolyze P(1)-P(4)-bis(5'- adenosyl) tetraphosphate (Ap4A), but has extremely low activity with ATP. Modulates transcriptional activation by CTNNB1 and thereby contributes to regulate the expression of genes essential for cell proliferation and survival, such as CCND1 and BIRC5. Plays a role in the induction of apoptosis via SRC and AKT1 signaling pathways. Inhibits MDM2-mediated proteasomal degradation of p53/TP53 and thereby plays a role in p53/TP53-mediated apoptosis. Induction of apoptosis depends on the ability of FHIT to bind P(1)-P(3)-bis(5'-adenosyl) triphosphate or related compounds, but does not require its catalytic activity, it may in part come from the mitochondrial form, which sensitizes the low- affinity Ca(2+) transporters, enhancing mitochondrial calcium uptake. Functions as tumor suppressor.

Molekulargewicht: 16858

UniProt: P49789