RBMX Antikörper (AA 222-252)

Produktnummer ABIN6244062

Der Kaninchen Polyklonal Anti-RBMX-Antikörper wurde für WB validiert. Er ist geeignet, RBMX in Proben von Human zu detektieren.

Kurzübersicht für RBMX Antikörper (AA 222-252) (ABIN6244062)

Target: RBMX (RNA Binding Motif Protein, X-Linked (RBMX))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser RBMX Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Klon: RB53800

Produktdetails anti-RBMX Antikörper

Bindungsspezifität: AA 222-252

Aufreinigung: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This RBMX antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 222-252 amino acids from the Central region of human RBMX.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: WB: 1:2000. WB: 1:2000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Haltbarkeit: 6 months

Details zu RBMX

Target: RBMX (RNA Binding Motif Protein, X-Linked (RBMX))

Andere Bezeichnung: RBMX

Hintergrund: RNA-binding protein that plays several role in the regulation of pre- and post-transcriptional processes. Implicated in tissue-specific regulation of gene transcription and alternative splicing of several pre-mRNAs. Binds to and stimulates transcription from the tumor suppressor TXNIP gene promoter, may thus be involved in tumor suppression. When associated with SAFB, binds to and stimulates transcription from the SREBF1 promoter. Associates with nascent mRNAs transcribed by RNA polymerase II. Component of the supraspliceosome complex that regulates pre-mRNA alternative splice site selection. Can either activate or suppress exon inclusion, acts additively with TRA2B to promote exon 7 inclusion of the survival motor neuron SMN2. Represses the splicing of MAPT/Tau exon 10. Binds preferentially to single- stranded 5'-CC[A/C]-rich RNA sequence motifs localized in a single-stranded conformation, probably binds RNA as a homodimer. Binds non-specifically to pre-mRNAs. Plays also a role in the cytoplasmic TNFR1 trafficking pathways, promotes both the IL-1- beta-mediated inducible proteolytic cleavage of TNFR1 ectodomains and the release of TNFR1 exosome-like vesicles to the extracellular compartment.

Molekulargewicht: 42332

UniProt: P38159

Pathways: Chromatin Binding, Ribonucleoprotein Complex Subunit Organization