ITK Antikörper (AA 228-262)

Produktnummer ABIN6243870

Der Kaninchen Polyklonal Anti-ITK-Antikörper wurde für WB validiert. Er ist geeignet, ITK in Proben von Human zu detektieren.

Kurzübersicht für ITK Antikörper (AA 228-262) (ABIN6243870)

Target: ITK (IL2-Inducible T-Cell Kinase (ITK))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ITK Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Klon: RB50773

Produktdetails anti-ITK Antikörper

Bindungsspezifität: AA 228-262

Homologie: M

Aufreinigung: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This ITK antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 228-262 amino acids from the Central region of human ITK.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: WB: 1:1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Haltbarkeit: 6 months

Details zu ITK

Target: ITK (IL2-Inducible T-Cell Kinase (ITK))

Andere Bezeichnung: ITK

Hintergrund: Tyrosine kinase that plays an essential role in regulation of the adaptive immune response. Regulates the development, function and differentiation of conventional T-cells and nonconventional NKT-cells. When antigen presenting cells (APC) activate T-cell receptor (TCR), a series of phosphorylation lead to the recruitment of ITK to the cell membrane, in the vicinity of the stimulated TCR receptor, where it is phosphorylated by LCK. Phosphorylation leads to ITK autophosphorylation and full activation. Once activated, phosphorylates PLCG1, leading to the activation of this lipase and subsequent cleavage of its substrates. In turn, the endoplasmic reticulum releases calcium in the cytoplasm and the nuclear activator of activated T-cells (NFAT) translocates into the nucleus to perform its transcriptional duty. Phosphorylates 2 essential adapter proteins: the linker for activation of T-cells/LAT protein and LCP2. Then, a large number of signaling molecules such as VAV1 are recruited and ultimately lead to lymphokine production, T-cell proliferation and differentiation.

Molekulargewicht: 71831

UniProt: Q08881

Pathways: T-Zell Rezeptor Signalweg, Fc-epsilon Rezeptor Signalübertragung