KANK2 Antikörper (AA 343-376)

Produktnummer ABIN6243798

Der Kaninchen Polyklonal anti-KANK2 Antikörper wird verwendet zum Nachweis von KANK2 in Proben von Human. Er wurde validiert für WB.

Kurzübersicht für KANK2 Antikörper (AA 343-376) (ABIN6243798)

Target: KANK2 (KN Motif and Ankyrin Repeat Domains 2 (KANK2))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser KANK2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Klon: RB48827

Produktdetails anti-KANK2 Antikörper

Bindungsspezifität: AA 343-376

Aufreinigung: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This KANK2 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 343-376 amino acids from the Central region of human KANK2.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: WB: 1:2000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Haltbarkeit: 6 months

Details zu KANK2

Target: KANK2 (KN Motif and Ankyrin Repeat Domains 2 (KANK2))

Andere Bezeichnung: KANK2

Hintergrund: Involved in transcription regulation by sequestering nuclear receptor coactivators, such as NCOA1, NCOA2 and NCOA3, in the cytoplasm, the function is deregulated by phosphorylation. Involved in the negative control of vitamin D receptor signaling pathway (PubMed:< a href="http://www.uniprot.org/citations/24671081" target="_blank">24671081). May be involved in the control of cytoskeleton formation by regulating actin polymerization. Involved in regulation of caspase-independent apoptosis, proposed to sequester AIFM1 in mitochondria and apoptotic stimuli lead to its proteasomal degradation allowing the release of AIFM1 to the nucleus (PubMed:< a href="http://www.uniprot.org/citations/22371500" target="_blank">22371500). May be involved in promotion of cell proliferation (By similarity).

Molekulargewicht: 91174

UniProt: Q63ZY3