Telefon:
+49 (0)241 95 163 153
Fax:
+49 (0)241 95 163 155
E-Mail:
orders@antikoerper-online.de

L3MBTL1 Antikörper (AA 451-485)

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch L3MBTL1 in WB. Er zeigt eine Reaktivität gegenüber Maus.
Produktnummer ABIN6243755

Kurzübersicht für L3MBTL1 Antikörper (AA 451-485) (ABIN6243755)

Target

Alle L3MBTL1 Antikörper anzeigen
L3MBTL1 (L(3)mbt-Like 1 (L3MBTL1))

Reaktivität

  • 21
  • 4
  • 3
  • 3
  • 3
  • 3
  • 2
  • 2
  • 1
Maus

Wirt

  • 18
  • 2
  • 2
Kaninchen

Klonalität

  • 18
  • 3
  • 1
Polyklonal

Konjugat

  • 21
  • 1
Dieser L3MBTL1 Antikörper ist unkonjugiert

Applikation

  • 14
  • 9
  • 6
  • 4
  • 4
  • 4
  • 3
  • 2
  • 2
  • 1
Western Blotting (WB)

Klon

RB53645
  • Bindungsspezifität

    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 451-485

    Aufreinigung

    This antibody is purified through a protein A column, followed by peptide affinity purification.

    Immunogen

    This L3MBTL1 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 451-485 amino acids from the Central region of human L3MBTL1.

    Isotyp

    Ig Fraction
  • Applikationshinweise

    WB: 1:2000

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Liquid

    Buffer

    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

    Konservierungsmittel

    Sodium azide

    Vorsichtsmaßnahmen

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Lagerung

    4 °C,-20 °C

    Haltbarkeit

    6 months
  • Target

    L3MBTL1 (L(3)mbt-Like 1 (L3MBTL1))

    Andere Bezeichnung

    L3MBTL1

    Hintergrund

    Polycomb group (PcG) protein that specifically recognizes and binds mono- and dimethyllysine residues on target proteins, therey acting as a 'reader' of a network of post- translational modifications. PcG proteins maintain the transcriptionally repressive state of genes: acts as a chromatin compaction factor by recognizing and binding mono- and dimethylated histone H1b/HIST1H1E at 'Lys-26' (H1bK26me1 and H1bK26me2) and histone H4 at 'Lys-20' (H4K20me1 and H4K20me2), leading to condense chromatin and repress transcription. Recognizes and binds p53/TP53 monomethylated at 'Lys-382', leading to repress p53/TP53-target genes. Also recognizes and binds RB1/RB monomethylated at 'Lys-860'. Participates in the ETV6-mediated repression. Probably plays a role in cell proliferation. Overexpression induces multinucleated cells, suggesting that it is required to accomplish normal mitosis.

    Molekulargewicht

    92297

    UniProt

    Q9Y468

    Pathways

    Chromatin Binding
Sie sind hier:
Chat with us!