COMMD1 Antikörper

Produktnummer ABIN6243631

Dieses Anti-COMMD1-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von COMMD1 in WB. Geeignet für Human.

Kurzübersicht für COMMD1 Antikörper (ABIN6243631)

Target: COMMD1 (Copper Metabolism (Murr1) Domain Containing 1 (COMMD1))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser COMMD1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Klon: RB54338

Produktdetails anti-COMMD1 Antikörper

Aufreinigung: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This COMMD1 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 4--33 amino acids from human COMMD1.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: WB: 1:2000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Haltbarkeit: 6 months

Details zu COMMD1

Target: COMMD1 (Copper Metabolism (Murr1) Domain Containing 1 (COMMD1))

Andere Bezeichnung: COMMD1

Hintergrund: Proposed scaffold protein that is implicated in diverse physiological processes and whose function may be in part linked to its ability to regulate ubiquitination of specific cellular proteins. Can modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes by displacing CAND1, in vitro promotes CRL E3 activiy and dissocoiates CAND1 from CUL1 and CUL2 (PubMed:< a href="http://www.uniprot.org/citations/21778237" target="_blank">21778237). Promotes ubiquitination of NF-kappa-B subunit RELA and its subsequent proteasomal degradation. Down-regulates NF-kappa-B activity (PubMed:< a href="http://www.uniprot.org/citations/15799966" target="_blank">15799966, PubMed:< a href="http://www.uniprot.org/citations/17183367" target="_blank">17183367, PubMed:< a href="http://www.uniprot.org/citations/20048074" target="_blank">20048074). Involved in the regulation of membrane expression and ubiquitination of SLC12A2 (PubMed:< a href="http://www.uniprot.org/citations/23515529" target="_blank">23515529). Modulates Na(+) transport in epithelial cells by regulation of apical cell surface expression of amiloride-sensitive sodium channel (ENaC) subunits and by promoting their ubiquitination presumably involving NEDD4L. Promotes the localization of SCNN1D to recycling endosomes (PubMed:< a href="http://www.uniprot.org/citations/14645214" target="_blank">14645214, PubMed:< a href="http://www.uniprot.org/citations/20237237" target="_blank">20237237, PubMed:< a href="http://www.uniprot.org/citations/21741370" target="_blank">21741370). Promotes CFTR cell surface expression through regulation of its ubiquitination (PubMed:< a href="http://www.uniprot.org/citations/21483833" target="_blank">21483833). Down-regulates SOD1 activity by interfering with its homodimerization (PubMed:< a href="http://www.uniprot.org/citations/20595380" target="_blank">20595380). Plays a role in copper ion homeostasis. Involved in copper-dependent ATP7A trafficking between the trans- Golgi network and vesicles in the cell periphery, the function is proposed to depend on its association within the CCC complex and cooperation with the WASH complex on early endosomes (PubMed:< a href="http://www.uniprot.org/citations/25355947" target="_blank">25355947). Can bind one copper ion per monomer (PubMed:< a href="http://www.uniprot.org/citations/17309234" target="_blank">17309234). May function to facilitate biliary copper excretion within hepatocytes. Binds to phosphatidylinositol 4,5- bisphosphate (PtdIns(4,5)P2) (PubMed:< a href="http://www.uniprot.org/citations/18940794" target="_blank">18940794). Involved in the regulation of HIF1A-mediated transcription, competes with ARNT/Hif-1-beta for binding to HIF1A resulting in decreased DNA binding and impaired transcriptional activation by HIF-1 (PubMed:< a href="http://www.uniprot.org/citations/20458141" target="_blank">20458141).

Molekulargewicht: 21178

UniProt: Q8N668

Pathways: Transition Metal Ion Homeostasis