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CHMP3 Antikörper (N-Term)

Der Kaninchen Polyklonal Anti-CHMP3-Antikörper wurde für WB validiert. Er ist geeignet, CHMP3 in Proben von Human und Maus zu detektieren.
Produktnummer ABIN6243582

Kurzübersicht für CHMP3 Antikörper (N-Term) (ABIN6243582)

Target

Alle CHMP3 Antikörper anzeigen
CHMP3 (Charged Multivesicular Body Protein 3 (CHMP3))

Reaktivität

  • 23
  • 9
  • 7
  • 3
  • 2
  • 2
  • 2
  • 1
  • 1
  • 1
Human, Maus

Wirt

  • 21
  • 2
Kaninchen

Klonalität

  • 20
  • 3
Polyklonal

Konjugat

  • 16
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Dieser CHMP3 Antikörper ist unkonjugiert

Applikation

  • 16
  • 8
  • 5
  • 4
  • 3
  • 2
  • 1
  • 1
Western Blotting (WB)

Klon

RB51722
  • Bindungsspezifität

    • 5
    • 1
    • 1
    • 1
    AA 28-61, N-Term

    Homologie

    B, Pr, Rat

    Aufreinigung

    This antibody is purified through a protein A column, followed by peptide affinity purification.

    Immunogen

    This CHMP3 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 28-61 amino acids from the N-terminal region of human CHMP3.

    Isotyp

    Ig Fraction
  • Applikationshinweise

    WB: 1:1000. WB: 1:1000

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Liquid

    Buffer

    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

    Konservierungsmittel

    Sodium azide

    Vorsichtsmaßnahmen

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Lagerung

    4 °C,-20 °C

    Haltbarkeit

    6 months
  • Target

    CHMP3 (Charged Multivesicular Body Protein 3 (CHMP3))

    Andere Bezeichnung

    CHMP3

    Hintergrund

    Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. Selectively binds to phosphatidylinositol 3,5-bisphosphate PtdIns(3,5)P2 and PtdIns(3,4)P2 in preference to other phosphoinositides tested. Involved in late stages of cytokinesis. Plays a role in endosomal sorting/trafficking of EGF receptor. Isoform 2 prevents stress- mediated cell death and accumulation of reactive oxygen species when expressed in yeast cells.

    Molekulargewicht

    25073

    UniProt

    Q9Y3E7
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