LARGE Antikörper (AA 365-398)

Produktnummer ABIN6243442

Dieses Anti-LARGE-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von LARGE in WB. Geeignet für Human.

Kurzübersicht für LARGE Antikörper (AA 365-398) (ABIN6243442)

Target: LARGE (Like-Glycosyltransferase (LARGE))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser LARGE Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Klon: RB55257

Produktdetails anti-LARGE Antikörper

Bindungsspezifität: AA 365-398

Homologie: C, Zf, M

Aufreinigung: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This LARGE antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 365-398 amino acids from the Central region of human LARGE.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: WB: 1:2000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Haltbarkeit: 6 months

Details zu LARGE

Target: LARGE (Like-Glycosyltransferase (LARGE))

Andere Bezeichnung: LARGE

Hintergrund: Bifunctional glycosyltransferase with both xylosyltransferase and beta-1,3-glucuronyltransferase activities involved in the biosynthesis of the phosphorylated O-mannosyl trisaccharide (N-acetylgalactosamine-beta-3-N-acetylglucosamine- beta-4-(phosphate-6-)mannose), a carbohydrate structure present in alpha-dystroglycan (DAG1) (PubMed:< a href="http://www.uniprot.org/citations/22223806" target="_blank">22223806). Phosphorylated O- mannosyl trisaccharid is required for binding laminin G-like domain-containing extracellular proteins with high affinity and plays a key role in skeletal muscle function and regeneration. LARGE elongates the glucuronyl-beta-1,4-xylose-beta disaccharide primer structure initiated by B3GNT1/B4GAT1 by adding repeating units [-3-Xylose-alpha-1,3-GlcA-beta-1-] to produce a heteropolysaccharide (PubMed:< a href="http://www.uniprot.org/citations/25279699" target="_blank">25279699).

Molekulargewicht: 88066

UniProt: O95461