KAT5 Antikörper (AA 367-398)

Produktnummer ABIN6243420

Der Kaninchen Polyklonal Anti-KAT5-Antikörper wurde für WB validiert. Er ist geeignet, KAT5 in Proben von Human zu detektieren.

Kurzübersicht für KAT5 Antikörper (AA 367-398) (ABIN6243420)

Target: KAT5 (K(lysine) Acetyltransferase 5 (KAT5))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser KAT5 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Klon: RB53893

Produktdetails anti-KAT5 Antikörper

Bindungsspezifität: AA 367-398

Aufreinigung: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This KAT5 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 367-398 amino acids from human KAT5.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: WB: 1:2000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Haltbarkeit: 6 months

Details zu KAT5

Target: KAT5 (K(lysine) Acetyltransferase 5 (KAT5))

Andere Bezeichnung: KAT5

Hintergrund: Catalytic subunit of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome-DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. Directly acetylates and activates ATM. Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AFZ from the nucleosome. In case of HIV-1 infection, interaction with the viral Tat protein leads to KAT5 polyubiquitination and targets it to degradation. Relieves NR1D2-mediated inhibition of APOC3 expression by acetylating NR1D2.

Molekulargewicht: 58582

UniProt: Q92993

Pathways: Intracellular Steroid Hormone Receptor Signaling Pathway