RUNX2 Antikörper (N-Term)

Produktnummer ABIN6243280

Zitiert in 1 Publikation. Der Kaninchen Polyklonal anti-RUNX2 Antikörper (Klon RB10543) (ABIN6243280) detektiert spezifisch RUNX2 in IHC (p). Dieser Antikörper reagiert spezifisch mit Proben aus Human.

Kurzübersicht für RUNX2 Antikörper (N-Term) (ABIN6243280)

Target: RUNX2 (Runt-Related Transcription Factor 2 (RUNX2))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser RUNX2 Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Klon: RB10543

Produktdetails anti-RUNX2 Antikörper

Bindungsspezifität: AA 1-30, N-Term

Aufreinigung: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This RUNX2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1~30 amino acids from the N-terminal region of human RUNX2.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: IHC-P: 1:10~50

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Haltbarkeit: 6 months

Referenzen für anti-RUNX2 Antikörper (ABIN6243280)

Ushijima, Okazaki, Tsushima, Iwamoto: "CCAAT/enhancer-binding protein β regulates the repression of type II collagen expression during the differentiation from proliferative to hypertrophic chondrocytes." in: The Journal of biological chemistry, Vol. 289, Issue 5, pp. 2852-63, (2014) (PubMed).

Details zu RUNX2

Target: RUNX2 (Runt-Related Transcription Factor 2 (RUNX2))

Andere Bezeichnung: RUNX2

Hintergrund: Runx2 is a member of the RUNX family of transcription factors. It is a nuclear protein with an Runt DNA-binding domain. This protein is essential for osteoblastic differentiation and skeletal morphogenesis and acts as a scaffold for nucleic acids and regulatory factors involved in skeletal gene expression. It can bind DNA both as a monomer or, with more affinity, as a subunit of a heterodimeric complex. Mutations in the Runx2 gene have been associated with the bone development disorder cleidocranial dysplasia (CCD).

Molekulargewicht: 56648

NCBI Accession: NP_001015051, NP_001019801

UniProt: Q13950