IFITM3 Antikörper (N-Term)

Produktnummer ABIN6243232

Dieses Anti-IFITM3-Antikörper ist ein Maus Monoklonal-Antikörper zur Detektion von IFITM3 in WB. Geeignet für Human.

Kurzübersicht für IFITM3 Antikörper (N-Term) (ABIN6243232)

Target: IFITM3 (Interferon-Induced Transmembrane Protein 3 (IFITM3))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser IFITM3 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Klon: 1082CT14-1-3-1

Produktdetails anti-IFITM3 Antikörper

Bindungsspezifität: AA 1-133, N-Term

Aufreinigung: This antibody is purified through a protein G column, followed by dialysis against PBS.

Immunogen: This IFITM3 antibody is generated from a mouse immunized with a recombinant protein KLH conjugated synthetic peptide between 1-133 amino acids from the N-terminal region of human IFITM3.

Isotyp: IgG1 kappa

Anwendungsinformationen

Applikationshinweise: WB: 1:4000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified monoclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Haltbarkeit: 6 months

Details zu IFITM3

Target: IFITM3 (Interferon-Induced Transmembrane Protein 3 (IFITM3))

Andere Bezeichnung: IFITM3

Hintergrund: IFN-induced antiviral protein which disrupts intracellular cholesterol homeostasis. Inhibits the entry of viruses to the host cell cytoplasm by preventing viral fusion with cholesterol depleted endosomes. May inactivate new enveloped viruses which buds out of the infected cell, by letting them go out with a cholesterol depleted membrane. Active against multiple viruses, including influenza A virus, SARS coronavirus (SARS-CoV), Marburg virus (MARV) and Ebola virus (EBOV), Dengue virus (DNV), West Nile virus (WNV), human immunodeficiency virus type 1 (HIV-1) and vesicular stomatitis virus (VSV). Can inhibit: influenza virus hemagglutinin protein-mediated viral entry, MARV and EBOV GP1,2- mediated viral entry, SARS-CoV S protein-mediated viral entry and VSV G protein-mediated viral entry. Plays a critical role in the structural stability and function of vacuolar ATPase (v-ATPase). Establishes physical contact with the v-ATPase of endosomes which is critical for proper clathrin localization and is also required for the function of the v-ATPase to lower the pH in phagocytic endosomes thus establishing an antiviral state.

Molekulargewicht: 14632

UniProt: Q01628