GRB14 Antikörper (AA 14-48)

Produktnummer ABIN6243218

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch GRB14 in WB, IF und FACS. Es zeigt Reaktivität gegenüber Proben von Human.

Kurzübersicht für GRB14 Antikörper (AA 14-48) (ABIN6243218)

Target: GRB14 (Growth Factor Receptor-Bound Protein 14 (GRB14))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser GRB14 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF), Flow Cytometry (FACS)

Klon: RB57897

Produktdetails anti-GRB14 Antikörper

Bindungsspezifität: AA 14-48

Aufreinigung: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This GRB14 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 14-48 amino acids from the human region of human GRB14.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: IF: 1:25. WB: 1:1000. FC: 1:25

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Haltbarkeit: 6 months

Details zu GRB14

Target: GRB14 (Growth Factor Receptor-Bound Protein 14 (GRB14))

Andere Bezeichnung: GRB14

Hintergrund: Adapter protein which modulates coupling of cell surface receptor kinases with specific signaling pathways. Binds to, and suppresses signals from, the activated insulin receptor (INSR). Potent inhibitor of insulin-stimulated MAPK3 phosphorylation. Plays a critical role regulating PDPK1 membrane translocation in response to insulin stimulation and serves as an adapter protein to recruit PDPK1 to activated insulin receptor, thus promoting PKB/AKT1 phosphorylation and transduction of the insulin signal.

Molekulargewicht: 60988

UniProt: Q14449