GPR56 Antikörper

Produktnummer ABIN6243208

Der Maus Monoklonal anti-GPR56 Antikörper (Klon 1443CT377-65-29) (ABIN6243208) detektiert spezifisch GPR56 in WB. Dieser Antikörper reagiert spezifisch mit Proben aus Human.

Kurzübersicht für GPR56 Antikörper (ABIN6243208)

Target: GPR56 (G Protein-Coupled Receptor 56 (GPR56))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser GPR56 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Klon: 1443CT377-65-29

Produktdetails anti-GPR56 Antikörper

Immunogen: This antibody is generated from a mouse immunized with a recombinant protein.

Isotyp: IgG1 kappa

Anwendungsinformationen

Applikationshinweise: WB: 1:2000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Lagerung: 4 °C,-20 °C

Haltbarkeit: 6 months

Details zu GPR56

Target: GPR56 (G Protein-Coupled Receptor 56 (GPR56))

Andere Bezeichnung: GPR56

Hintergrund: Involved in cell adhesion and probably in cell-cell interactions. Regulates the migration of neural precursor cells. Receptor for collagen III/COL3A1 in the developing brain and involved in regulation of cortical development, specifically in maintenance of the pial basemant membrane integrity and in cortical lamination. Binding to the COL3A1 ligand inhibits neuronal migration and activates the RhoA pathway by coupling to GNA13 and possibly GNA12. Isoforms show differences in receptor signaling, specifically in serum response element (SRE) transcriptional activation upon overexpression. Overexpression inhibits melanoma tumor growth and metastasis and, during melanoma progression, regulates VEGFA production and angiogenesis through PRKCA, unprocessed GPR56 is inhibiting and GPR56 NT is activating angiogenesis.

Molekulargewicht: 77738

UniProt: Q9Y653