FZR1 Antikörper (AA 1-496)

Produktnummer ABIN6243204

Der Maus Monoklonal Anti-FZR1-Antikörper wurde für WB validiert. Er ist geeignet, FZR1 in Proben von Human zu detektieren.

Kurzübersicht für FZR1 Antikörper (AA 1-496) (ABIN6243204)

Target: FZR1 (Fizzy/cell Division Cycle 20 Related 1 (FZR1))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser FZR1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Klon: 1621CT637-76-67

Produktdetails anti-FZR1 Antikörper

Bindungsspezifität: AA 1-496

Aufreinigung: This antibody is purified through a protein G column, followed by dialysis against PBS.

Immunogen: This FZR antibody is generated from a mouse immunized with a recombinant protein between1-496 amino acids from human FZR.

Isotyp: IgG1 kappa

Anwendungsinformationen

Applikationshinweise: WB: 1:2000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified monoclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Haltbarkeit: 6 months

Details zu FZR1

Target: FZR1 (Fizzy/cell Division Cycle 20 Related 1 (FZR1))

Andere Bezeichnung: FZR

Hintergrund: Key regulator of ligase activity of the anaphase promoting complex/cyclosome (APC/C), which confers substrate specificity upon the complex. Associates with the APC/C in late mitosis, in replacement of CDC20, and activates the APC/C during anaphase and telophase. The APC/C remains active in degrading substrates to ensure that positive regulators of the cell cycle do not accumulate prematurely. At the G1/S transition FZR1 is phosphorylated, leading to its dissociation from the APC/C. Following DNA damage, it is required for the G2 DNA damage checkpoint: its dephosphorylation and reassociation with the APC/C leads to the ubiquitination of PLK1, preventing entry into mitosis.

Molekulargewicht: 55179

UniProt: Q9UM11

Pathways: DNA Replication, Synthesis of DNA