DNMT3B Antikörper (AA 356-390)

Produktnummer ABIN6243167

Produktdetails anti-DNMT3B Antikörper

Target: DNMT3B (DNA (Cytosine-5-)-Methyltransferase 3 beta (DNMT3B))

Bindungsspezifität: AA 356-390

Reaktivität: Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser DNMT3B Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Aufreinigung: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This Mouse Dnmt3b antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 356-390 amino acids from the Central region of Mouse Dnmt3b.

Klon: RB50993

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: WB: 1:2000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Haltbarkeit: 6 months

Details zu DNMT3B

Target: DNMT3B (DNA (Cytosine-5-)-Methyltransferase 3 beta (DNMT3B))

Andere Bezeichnung: Dnmt3b (DNMT3B Produkte)

Synonyme: DNMT3B antikoerper, LOC100218113 antikoerper, ICF antikoerper, ICF1 antikoerper, M.HsaIIIB antikoerper, MmuIIIB antikoerper, cb91 antikoerper, dnmt3bl antikoerper, dnmt7 antikoerper, sb:cb91 antikoerper, wu:fb16h07 antikoerper, DNA methyltransferase 3 beta antikoerper, DNA methyltransferase 3B antikoerper, DNA (cytosine-5-)-methyltransferase 3 beta, duplicate a antikoerper, DNMT3B antikoerper, Dnmt3b antikoerper, dnmt3b antikoerper, dnmt3ba antikoerper

Hintergrund: Required for genome-wide de novo methylation and is essential for the establishment of DNA methylation patterns during development. DNA methylation is coordinated with methylation of histones. May preferentially methylates nucleosomal DNA within the nucleosome core region. May function as transcriptional co- repressor by associating with CBX4 and independently of DNA methylation. Seems to be involved in gene silencing. In association with DNMT1 and via the recruitment of CTCFL/BORIS, involved in activation of BAG1 gene expression by modulating dimethylation of promoter histone H3 at H3K4 and H3K9. Function as transcriptional corepressor by associating with ZHX1 (By similarity).

Molekulargewicht: 97228

UniProt: O88509