CYR61 Antikörper (AA 143-174)

Produktnummer ABIN6243134

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch CYR61 in WB. Es zeigt Reaktivität gegenüber Proben von Human.

Kurzübersicht für CYR61 Antikörper (AA 143-174) (ABIN6243134)

Target: CYR61 (Cysteine-Rich, Angiogenic Inducer, 61 (CYR61))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CYR61 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Klon: RB53929

Produktdetails anti-CYR61 Antikörper

Bindungsspezifität: AA 143-174

Aufreinigung: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This CYR61 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 143-174 amino acids from the Central region of human CYR61.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: WB: 1:2000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Haltbarkeit: 6 months

Details zu CYR61

Target: CYR61 (Cysteine-Rich, Angiogenic Inducer, 61 (CYR61))

Andere Bezeichnung: CYR61

Hintergrund: Promotes cell proliferation, chemotaxis, angiogenesis and cell adhesion. Appears to play a role in wound healing by up- regulating, in skin fibroblasts, the expression of a number of genes involved in angiogenesis, inflammation and matrix remodeling including VEGA-A, VEGA-C, MMP1, MMP3, TIMP1, uPA, PAI-1 and integrins alpha-3 and alpha-5. CYR61-mediated gene regulation is dependent on heparin-binding. Down-regulates the expression of alpha-1 and alpha-2 subunits of collagen type-1. Promotes cell adhesion and adhesive signaling through integrin alpha-6/beta-1, cell migration through integrin alpha-v/beta-5 and cell proliferation through integrin alpha-v/beta-3.

Molekulargewicht: 42027

UniProt: O00622

Pathways: Positive Regulation of Endopeptidase Activity, Growth Factor Binding