RGS19 Antikörper (N-Term)

Produktnummer ABIN6243052

Zitiert in 2+ Publikationen. Der Kaninchen Polyklonal anti-RGS19 Antikörper (Klon RB7576) (ABIN6243052) detektiert spezifisch RGS19 in WB und IHC (p). Dieser Antikörper reagiert spezifisch mit Proben aus Human.

Kurzübersicht für RGS19 Antikörper (N-Term) (ABIN6243052)

Target: RGS19 (Regulator of G-Protein Signalling 19 (RGS19))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser RGS19 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Klon: RB7576

Produktdetails anti-RGS19 Antikörper

Bindungsspezifität: AA 1-30, N-Term

Aufreinigung: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogen: This RGS19 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1~30 amino acids from the N-term of human RGS19.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: WB: 1:2000. IHC-P: 1:50~100

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Haltbarkeit: 6 months

Referenzen für anti-RGS19 Antikörper (ABIN6243052)

Li, Wang, Chen, Lu, Wang, Duan, Tian, Wang, You, Zou, Cheng, Zhu, Wan, Xi, Jiang, Han, Cao, Birnbaumer, Chu, Yang: "Gαi1 and Gαi3 regulate macrophage polarization by forming a complex containing CD14 and Gab1." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 112, Issue 15, pp. 4731-6, (2015) (PubMed).

Sanchez, Penfornis, Oskowitz, Boonjindasup, Cai, Dhule, Rowan, Kelekar, Krause, Pochampally: "Activation of autophagy in mesenchymal stem cells provides tumor stromal support." in: Carcinogenesis, Vol. 32, Issue 7, pp. 964-72, (2011) (PubMed).

Details zu RGS19

Target: RGS19 (Regulator of G-Protein Signalling 19 (RGS19))

Andere Bezeichnung: RGS19

Hintergrund: Macroautophagy is the major inducible pathway for the general turnover of cytoplasmic constituents in eukaryotic cells, it is also responsible for the degradation of active cytoplasmic enzymes and organelles during nutrient starvation. Macroautophagy involves the formation of double-membrane bound autophagosomes which enclose the cytoplasmic constituent targeted for degradation in a membrane bound structure, which then fuse with the lysosome (or vacuole) releasing a single-membrane bound autophagic bodies which are then degraded within the lysosome (or vacuole). RGS19 enhances the intrinsic GTPase-activating protein activity of the Galphai3 protein, which stimulates autophagy by favoring the GDP-bound form of Galphai3.

Molekulargewicht: 24636

NCBI Accession: NP_001034556, NP_005864

UniProt: P49795

Pathways: Myometrial Relaxation and Contraction, Regulation of G-Protein Coupled Receptor Protein Signaling