NCOA2 Antikörper (AA 706-739)

Produktnummer ABIN6242927

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch NCOA2 in WB. Er zeigt eine Reaktivität gegenüber Human.

Kurzübersicht für NCOA2 Antikörper (AA 706-739) (ABIN6242927)

Target: NCOA2 (Nuclear Receptor Coactivator 2 (NCOA2))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser NCOA2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Klon: RB54073

Produktdetails anti-NCOA2 Antikörper

Bindungsspezifität: AA 706-739

Aufreinigung: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This NCOA2 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 706-739 amino acids from the Central region of human NCOA2.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: WB: 1:1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Haltbarkeit: 6 months

Details zu NCOA2

Target: NCOA2 (Nuclear Receptor Coactivator 2 (NCOA2))

Andere Bezeichnung: NCOA2

Hintergrund: Transcriptional coactivator for steroid receptors and nuclear receptors. Coactivator of the steroid binding domain (AF- 2) but not of the modulating N-terminal domain (AF-1). Required with NCOA1 to control energy balance between white and brown adipose tissues. Critical regulator of glucose metabolism regulation, acts as RORA coactivator to specifically modulate G6PC expression. Involved in the positive regulation of the transcriptional activity of the glucocorticoid receptor NR3C1 by sumoylation enhancer RWDD3. Positively regulates the circadian clock by acting as a transcriptional coactivator for the CLOCK- ARNTL/BMAL1 heterodimer (By similarity).

Molekulargewicht: 159157

UniProt: Q15596

Pathways: Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling, Nuclear Hormone Receptor Binding, Regulation of Lipid Metabolism by PPARalpha, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, CXCR4-mediated Signaling Events, Thromboxane A2 Receptor Signaling