PPP6C Antikörper (C-Term)

Produktnummer ABIN6242920

Dieses Anti-PPP6C-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von PPP6C in WB und IHC (p). Geeignet für Human. Dieses Primary Antibody wurde in 1 Publikation zitiert.

Kurzübersicht für PPP6C Antikörper (C-Term) (ABIN6242920)

Target: PPP6C (Protein Phosphatase 6, Catalytic Subunit (PPP6C))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PPP6C Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Klon: RB5867

Produktdetails anti-PPP6C Antikörper

Bindungsspezifität: AA 275-305, C-Term

Homologie: M, Rat

Aufreinigung: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogen: This PPP6C antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 275-305 amino acids from the C-terminal region of human PPP6C.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: WB: 1:1000. IHC-P: 1:50~100

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Haltbarkeit: 6 months

Referenzen für anti-PPP6C Antikörper (ABIN6242920)

Williams, Filter, Blake-Hodek, Wadzinski, Fuda, Shalloway, Goldberg: "Greatwall-phosphorylated Endosulfine is both an inhibitor and a substrate of PP2A-B55 heterotrimers." in: eLife, Vol. 3, pp. e01695, (2014) (PubMed).

Details zu PPP6C

Target: PPP6C (Protein Phosphatase 6, Catalytic Subunit (PPP6C))

Andere Bezeichnung: PPP6C

Hintergrund: PPP6C belongs to the PPP phosphatase family, PP-V subfamily. Reversible phosphorylation of proteins on serine and threonine residues is an important biochemical event that regulates a broad variety of intracellular processes. The phosphorylation state is determined by the well-controlled balance of activities of serine/threonine-specific protein kinases and protein phosphatases, including PPP6C. Expression levels are highest in testis, heart, and skeletal muscle and lowest in placenta, lung, and kidney. PPP6C can complement mutations in the S. cerevisiae Sit4 and S. pombe ppe1 genes, indicating that PPP6C is the functional homolog of yeast Sit4p and ppe1. Since Sit4p is required for the G1 to S transition of the cell cycle and ppe1 is involved in cell shape control and mitotic division, it has been suggested that PPP6C functions in cell cycle regulation.

Molekulargewicht: 35144

NCBI Accession: NP_001116827, NP_001116841, NP_002712

UniProt: O00743