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JARID2 Antikörper (AA 435-468)

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch JARID2 in WB. Er zeigt eine Reaktivität gegenüber Maus.
Produktnummer ABIN6242858

Kurzübersicht für JARID2 Antikörper (AA 435-468) (ABIN6242858)

Target

Alle JARID2 Antikörper anzeigen
JARID2 (Jumonji, AT Rich Interactive Domain 2 (JARID2))

Reaktivität

  • 43
  • 16
  • 8
  • 3
  • 2
  • 2
  • 2
  • 1
  • 1
Maus

Wirt

  • 33
  • 9
  • 2
  • 1
Kaninchen

Klonalität

  • 34
  • 11
Polyklonal

Konjugat

  • 20
  • 3
  • 3
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Dieser JARID2 Antikörper ist unkonjugiert

Applikation

  • 30
  • 13
  • 13
  • 12
  • 4
  • 4
  • 3
  • 3
  • 1
  • 1
  • 1
Western Blotting (WB)

Klon

RB52498
  • Bindungsspezifität

    • 15
    • 7
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 435-468

    Aufreinigung

    This antibody is purified through a protein A column, followed by peptide affinity purification.

    Immunogen

    This Mouse Jarid2 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 435-468 amino acids from the Central region of Mouse Jarid2.

    Isotyp

    Ig Fraction
  • Applikationshinweise

    WB: 1:2000

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Liquid

    Buffer

    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

    Konservierungsmittel

    Sodium azide

    Vorsichtsmaßnahmen

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Lagerung

    4 °C,-20 °C

    Haltbarkeit

    6 months
  • Target

    JARID2 (Jumonji, AT Rich Interactive Domain 2 (JARID2))

    Andere Bezeichnung

    Jarid2

    Hintergrund

    Regulator of histone methyltransferase complexes that plays an essential role in embryonic development, including heart and liver development, neural tube fusion process and hematopoiesis. Acts by modulating histone methyltransferase activity and promoting the recruitment of histone methyltransferase complexes to their target genes. Binds DNA and mediates the recruitment of the PRC2 complex to target genes in embryonic stem cells. Does not have histone demethylase activity but regulates activity of various histone methyltransferase complexes. In embryonic stem cells, it associates with the PRC2 complex and inhibits trimethylation of 'Lys-27' of histone H3 (H3K27me3) by the PRC2 complex, thereby playing a key role in differentiation of embryonic stem cells and normal development. In cardiac cells, it is required to repress expression of cyclin-D1 (CCND1) by activating methylation of 'Lys-9' of histone H3 (H3K9me) by the GLP1/EHMT1 and G9a/EHMT2 histone methyltransferases. Also acts as a transcriptional repressor of ANF via its interaction with GATA4 and NKX2-5. Participates in the negative regulation of cell proliferation signaling.

    Molekulargewicht

    137445

    UniProt

    Q62315

    Pathways

    Chromatin Binding
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