DIAPH1 Antikörper (N-Term)

Produktnummer ABIN6242839

Dieses Anti-DIAPH1-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von DIAPH1 in WB. Geeignet für Human.

Kurzübersicht für DIAPH1 Antikörper (N-Term) (ABIN6242839)

Target: DIAPH1 (Diaphanous Homolog 1 (DIAPH1))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser DIAPH1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Klon: RB30760

Produktdetails anti-DIAPH1 Antikörper

Bindungsspezifität: AA 18-52, N-Term

Aufreinigung: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This DIAPH1 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 18-52 amino acids from the N-terminal region of human DIAPH1.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: WB: 1:500-1:1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Haltbarkeit: 6 months

Details zu DIAPH1

Target: DIAPH1 (Diaphanous Homolog 1 (DIAPH1))

Andere Bezeichnung: DIAPH1

Hintergrund: Acts in a Rho-dependent manner to recruit PFY1 to the membrane. Required for the assembly of F-actin structures, such as actin cables and stress fibers. Nucleates actin filaments. Binds to the barbed end of the actin filament and slows down actin polymerization and depolymerization. Required for cytokinesis, and transcriptional activation of the serum response factor. DFR proteins couple Rho and Src tyrosine kinase during signaling and the regulation of actin dynamics. Functions as a scaffold protein for MAPRE1 and APC to stabilize microtubules and promote cell migration (By similarity). Has neurite outgrowth promoting activity (By similarity). In hear cells, it may play a role in the regulation of actin polymerization in hair cells. The MEMO1-RHOA- DIAPH1 signaling pathway plays an important role in ERBB2- dependent stabilization of microtubules at the cell cortex. It controls the localization of APC and CLASP2 to the cell membrane, via the regulation of GSK3B activity. In turn, membrane-bound APC allows the localization of the MACF1 to the cell membrane, which is required for microtubule capture and stabilization. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape.

Molekulargewicht: 141347

UniProt: O60610

Pathways: Sensory Perception of Sound