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SLUG Antikörper (AA 98-129)

Reaktivität: Human, Ratte, Maus WB, IHC (p), IF Wirt: Kaninchen Polyclonal RB01398 unconjugated
Produktnummer ABIN6242822
  • Target Alle SLUG Produkte
    SLUG
    Bindungsspezifität
    • 15
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 98-129
    Reaktivität
    • 26
    • 17
    • 15
    • 6
    • 1
    • 1
    • 1
    Human, Ratte, Maus
    Wirt
    • 24
    • 2
    Kaninchen
    Klonalität
    • 23
    • 3
    Polyklonal
    Konjugat
    • 11
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser SLUG Antikörper ist unkonjugiert
    Applikation
    • 25
    • 13
    • 13
    • 9
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF)
    Homologie
    B
    Aufreinigung
    This antibody is purified through a protein A column, followed by peptide affinity purification.
    Immunogen
    This SLUG antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 98-129 amino acids from the Central region of human SLUG.
    Klon
    RB01398
    Isotyp
    Ig Fraction
  • Applikationshinweise
    IF: 1:10~50. WB: 1:2000. WB: 1:1000. IHC-P: 1:10~50
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Buffer
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C,-20 °C
    Haltbarkeit
    6 months
  • Carpenter, Paw, Dewhirst, Lo: "Akt phosphorylates and activates HSF-1 independent of heat shock, leading to Slug overexpression and epithelial-mesenchymal transition (EMT) of HER2-overexpressing breast cancer cells." in: Oncogene, Vol. 34, Issue 5, pp. 546-57, (2015) (PubMed).

    Ferrari-Amorotti, Fragliasso, Esteki, Prudente, Soliera, Cattelani, Manzotti, Grisendi, Dominici, Pieraccioli, Raschellà, Chiodoni, Colombo, Calabretta: "Inhibiting interactions of lysine demethylase LSD1 with snail/slug blocks cancer cell invasion." in: Cancer research, Vol. 73, Issue 1, pp. 235-45, (2013) (PubMed).

    Lemma, Karihtala, Haapasaari, Jantunen, Soini, Bloigu, Pasanen, Turpeenniemi-Hujanen, Kuittinen: "Biological roles and prognostic values of the epithelial-mesenchymal transition-mediating transcription factors Twist, ZEB1 and Slug in diffuse large B-cell lymphoma." in: Histopathology, Vol. 62, Issue 2, pp. 326-33, (2012) (PubMed).

  • Target
    SLUG
    Abstract
    SLUG Produkte
    Synonyme
    Slug antikoerper, Slugh antikoerper, Snail2 antikoerper, SLUG antikoerper, SLUGH antikoerper, SLUGH1 antikoerper, SNAIL2 antikoerper, WS2D antikoerper, snail family zinc finger 2 antikoerper, snail family transcriptional repressor 2 antikoerper, Snai2 antikoerper, SNAI2 antikoerper
    Hintergrund
    SLUG is a member of the Snail family of C2H2-type zinc finger transcription factors. The encoded protein acts as a transcriptional repressor that binds to E-box motifs and is also likely to repress E-cadherin transcription in breast carcinoma. This protein is involved in epithelial-mesenchymal transitions and has antiapoptotic activity. Mutations in this gene may be associated with sporadic cases of neural tube defects.
    Molekulargewicht
    29986
    NCBI Accession
    NP_003059
    UniProt
    O43623
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