SYNE2 Antikörper (AA 1843-1877)

Produktnummer ABIN6242751

Der Kaninchen Polyklonal anti-SYNE2 Antikörper wird verwendet zum Nachweis von SYNE2 in Proben von Human. Er wurde validiert für WB und IHC (p).

Kurzübersicht für SYNE2 Antikörper (AA 1843-1877) (ABIN6242751)

Target: SYNE2 (Spectrin Repeat Containing, Nuclear Envelope 2 (SYNE2))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SYNE2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Klon: RB56750

Produktdetails anti-SYNE2 Antikörper

Bindungsspezifität: AA 1843-1877

Aufreinigung: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This SYNE2 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 1843-1877 amino acids from human SYNE2.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: WB: 1:1000. IHC-P: 1:25

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Haltbarkeit: 6 months

Details zu SYNE2

Target: SYNE2 (Spectrin Repeat Containing, Nuclear Envelope 2 (SYNE2))

Andere Bezeichnung: SYNE2

Hintergrund: Multi-isomeric modular protein which forms a linking network between organelles and the actin cytoskeleton to maintain the subcellular spatial organization. Component of SUN-protein- containing multivariate complexes also called LINC complexes which link the nucleoskeleton and cytoskeleton by providing versatile outer nuclear membrane attachment sites for cytoskeletal filaments. Involved in the maintenance of nuclear organization and structural integrity. Connects nuclei to the cytoskeleton by interacting with the nuclear envelope and with F-actin in the cytoplasm. Specifically, SYNE2 and SUN2 assemble in arrays of transmembrane actin-associated nuclear (TAN) lines which are bound to F-actin cables and couple the nucleus to retrograde actin flow during actin-dependent nuclear movement. Required for centrosome migration to the apical cell surface during early ciliogenesis.

Molekulargewicht: 796442

UniProt: Q8WXH0

Pathways: Maintenance of Protein Location