PCGF1 Antikörper (AA 117-151)

Produktnummer ABIN6242736

Der Kaninchen Polyklonal Anti-PCGF1-Antikörper wurde für WB validiert. Er ist geeignet, PCGF1 in Proben von Human, Maus und Ratte zu detektieren.

Kurzübersicht für PCGF1 Antikörper (AA 117-151) (ABIN6242736)

Target: PCGF1 (Polycomb Group Ring Finger 1 (PCGF1))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PCGF1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Klon: RB51308

Produktdetails anti-PCGF1 Antikörper

Bindungsspezifität: AA 117-151

Homologie: B

Aufreinigung: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This PCGF1 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 117-151 amino acids from the Central region of human PCGF1.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: WB: 1:1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Haltbarkeit: 6 months

Details zu PCGF1

Target: PCGF1 (Polycomb Group Ring Finger 1 (PCGF1))

Andere Bezeichnung: PCGF1

Hintergrund: Component of the Polycomb group (PcG) multiprotein BCOR complex, a complex required to maintain the transcriptionally repressive state of some genes, such as BCL6 and the cyclin- dependent kinase inhibitor, CDKN1A. Transcriptional repressor that may be targeted to the DNA by BCL6, this transcription repressor activity may be related to PKC signaling pathway. Represses CDKN1A expression by binding to its promoter, and this repression is dependent on the retinoic acid response element (RARE element). Promotes cell cycle progression and enhances cell proliferation as well. May have a positive role in tumor cell growth by down- regulating CDKN1A. Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones, it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility.

Molekulargewicht: 30346

UniProt: Q9BSM1