XAF1 Antikörper (C-Term)

Produktnummer ABIN6242701

Dieses Anti-XAF1-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von XAF1 in WB und IF. Geeignet für Human.

Kurzübersicht für XAF1 Antikörper (C-Term) (ABIN6242701)

Target: XAF1 (XiAP Associated Factor 1 (XAF1))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser XAF1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF)

Klon: RB49525

Produktdetails anti-XAF1 Antikörper

Bindungsspezifität: AA 235-269, C-Term

Aufreinigung: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This XAF1 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 235-269 amino acids from the C-terminal region of human XAF1.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: IF: 1:25. WB: 1:1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Haltbarkeit: 6 months

Details zu XAF1

Target: XAF1 (XiAP Associated Factor 1 (XAF1))

Andere Bezeichnung: XAF1

Hintergrund: Seems to function as a negative regulator of members of the IAP (inhibitor of apoptosis protein) family. Inhibits anti- caspase activity of BIRC4. Induces cleavage and inactivation of BIRC4 independent of caspase activation. Mediates TNF-alpha- induced apoptosis and is involved in apoptosis in trophoblast cells. May inhibit BIRC4 indirectly by activating the mitochondrial apoptosis pathway. After translocation to mitochondra, promotes translocation of BAX to mitochondria and cytochrome c release from mitochondria. Seems to promote the redistribution of BIRC4 from the cytoplasm to the nucleus, probably independent of BIRC4 inactivation which seems to occur in the cytoplasm. The BIRC4-XAF1 complex mediates down-regulation of BIRC5/survivin, the process requires the E3 ligase activity of BIRC4. Seems to be involved in cellular sensitivity to the proapoptotic actions of TRAIL. May be a tumor suppressor by mediating apoptosis resistance of cancer cells.

Molekulargewicht: 34626

UniProt: Q6GPH4