VAV3 Antikörper (C-Term)

Produktnummer ABIN6242692

Dieses Anti-VAV3-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von VAV3 in WB. Geeignet für Human.

Kurzübersicht für VAV3 Antikörper (C-Term) (ABIN6242692)

Target: VAV3 (Vav 3 Oncogene (VAV3))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser VAV3 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Klon: RB53259

Produktdetails anti-VAV3 Antikörper

Bindungsspezifität: AA 768-802, C-Term

Aufreinigung: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This VAV3 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 768-802 amino acids from the C-terminal region of human VAV3.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: WB: 1:2000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Haltbarkeit: 6 months

Details zu VAV3

Target: VAV3 (Vav 3 Oncogene (VAV3))

Andere Bezeichnung: VAV3

Hintergrund: Exchange factor for GTP-binding proteins RhoA, RhoG and, to a lesser extent, Rac1. Binds physically to the nucleotide-free states of those GTPases. Plays an important role in angiogenesis. Its recruitment by phosphorylated EPHA2 is critical for EFNA1- induced RAC1 GTPase activation and vascular endothelial cell migration and assembly (By similarity). May be important for integrin-mediated signaling, at least in some cell types. In osteoclasts, along with SYK tyrosine kinase, required for signaling through integrin alpha-v/beta-1 (ITAGV-ITGB1), a crucial event for osteoclast proper cytoskeleton organization and function. This signaling pathway involves RAC1, but not RHO, activation. Necessary for proper wound healing. In the course of wound healing, required for the phagocytotic cup formation preceding macrophage phagocytosis of apoptotic neutrophils. Responsible for integrin beta-2 (ITGB2)-mediated macrophage adhesion and, to a lesser extent, contributes to beta-3 (ITGB3)- mediated adhesion. Does not affect integrin beta-1 (ITGB1)- mediated adhesion (By similarity).

Molekulargewicht: 97776

UniProt: Q9UKW4

Pathways: Fc-epsilon Rezeptor Signalübertragung, Neurotrophin Signalübertragung