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RNF2 Antikörper (AA 165-199)

RNF2 Reaktivität: Human, Maus WB Wirt: Kaninchen Polyclonal RB52402 unconjugated
Produktnummer ABIN6242607
  • Target Alle RNF2 Antikörper anzeigen
    RNF2 (Ring Finger Protein 2 (RNF2))
    Bindungsspezifität
    • 4
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 165-199
    Reaktivität
    • 48
    • 27
    • 21
    • 6
    • 6
    • 5
    • 5
    • 4
    • 4
    • 4
    • 4
    • 4
    • 3
    • 3
    • 2
    Human, Maus
    Wirt
    • 39
    • 7
    • 2
    • 1
    Kaninchen
    Klonalität
    • 38
    • 11
    Polyklonal
    Konjugat
    • 36
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser RNF2 Antikörper ist unkonjugiert
    Applikation
    • 35
    • 19
    • 12
    • 10
    • 10
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB)
    Aufreinigung
    This antibody is purified through a protein A column, followed by peptide affinity purification.
    Immunogen
    This mouse Rnf2 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 165-199 amino acids from the Central region of mouse Rnf2.
    Klon
    RB52402
    Isotyp
    Ig Fraction
    Top Product
    Discover our top product RNF2 Primärantikörper
  • Applikationshinweise
    WB: 1:1000. WB: 1:2000
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Buffer
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C,-20 °C
    Haltbarkeit
    6 months
  • Target
    RNF2 (Ring Finger Protein 2 (RNF2))
    Andere Bezeichnung
    Rnf2 (RNF2 Produkte)
    Synonyme
    BAP-1 antikoerper, BAP1 antikoerper, DING antikoerper, HIPI3 antikoerper, RING1B antikoerper, RING2 antikoerper, AI326319 antikoerper, AI450156 antikoerper, AU019207 antikoerper, Ring1B antikoerper, dinG antikoerper, fa19h05 antikoerper, ring1b antikoerper, wu:fa19h05 antikoerper, wz4556 antikoerper, bap-1 antikoerper, bap1 antikoerper, ding antikoerper, hipi3 antikoerper, ring2 antikoerper, ring finger protein 2 antikoerper, ring finger protein 2 L homeolog antikoerper, RNF2 antikoerper, Rnf2 antikoerper, rnf2 antikoerper, rnf2.L antikoerper
    Hintergrund
    E3 ubiquitin-protein ligase that mediates monoubiquitination of 'Lys-119' of histone H2A (H2AK119Ub), thereby playing a central role in histone code and gene regulation. H2AK119Ub gives a specific tag for epigenetic transcriptional repression and participates in X chromosome inactivation of female mammals. May be involved in the initiation of both imprinted and random X inactivation. Essential component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones, rendering chromatin heritably changed in its expressibility. E3 ubiquitin-protein ligase activity is enhanced by BMI1/PCGF4. Acts as the main E3 ubiquitin ligase on histone H2A of the PRC1 complex, while RING1 may rather act as a modulator of RNF2/RING2 activity. Association to the chromosomal DNA is cell-cycle dependent. In resting B- and T-lymphocytes, interaction with AURKB leads to block its activity, thereby maintaining transcription in resting lymphocytes.
    Molekulargewicht
    37623
    UniProt
    Q9CQJ4
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