RING1 Antikörper (C-Term)

Produktnummer ABIN6242605

Der Kaninchen Polyklonal anti-RING1 Antikörper (Klon RB51604) (ABIN6242605) detektiert spezifisch RING1 in WB. Dieser Antikörper reagiert spezifisch mit Proben aus Human und Ratte.

Kurzübersicht für RING1 Antikörper (C-Term) (ABIN6242605)

Target: RING1 (Ring Finger Protein 1 (RING1))

Reaktivität: Human, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser RING1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Klon: RB51604

Produktdetails anti-RING1 Antikörper

Bindungsspezifität: AA 279-313, C-Term

Homologie: M

Aufreinigung: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This RING1 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 279-313 amino acids from the C-terminal region of human RING1.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: WB: 1:1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Haltbarkeit: 6 months

Details zu RING1

Target: RING1 (Ring Finger Protein 1 (RING1))

Andere Bezeichnung: RING1

Hintergrund: Constitutes one of the E3 ubiquitin-protein ligases that mediate monoubiquitination of 'Lys-119' of histone H2A, thereby playing a central role in histone code and gene regulation. H2A 'Lys-119' ubiquitination gives a specific tag for epigenetic transcriptional repression and participates in X chromosome inactivation of female mammals. Essential component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones, rendering chromatin heritably changed in its expressibility. Compared to RNF2/RING2, it does not have the main E3 ubiquitin ligase activity on histone H2A, and it may rather act as a modulator of RNF2/RING2 activity.

Molekulargewicht: 42429

UniProt: Q06587