MUC4 Antikörper (N-Term)

Produktnummer ABIN6242467

Dieses Anti-MUC4-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von MUC4 in WB. Geeignet für Human.

Kurzübersicht für MUC4 Antikörper (N-Term) (ABIN6242467)

Target: MUC4 (Mucin 4, Cell Surface Associated (MUC4))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser MUC4 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Klon: RB49957

Produktdetails anti-MUC4 Antikörper

Bindungsspezifität: AA 529-560, N-Term

Aufreinigung: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This MUC4(Mucin-4 alpha chain) antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 529-560 amino acids from the N-terminal region of human MUC4(Mucin-4 alpha chain).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB: 1:1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Haltbarkeit: 6 months

Details zu MUC4

Target: MUC4 (Mucin 4, Cell Surface Associated (MUC4))

Andere Bezeichnung: MUC4(Mucin-4 alpha chain)

Hintergrund: May play a role in tumor progression. Ability to promote tumor growth may be mainly due to repression of apoptosis as opposed to proliferation. Has anti-adhesive properties. Seems to alter cellular behavior through both anti-adhesive effects on cell-cell and cell-extracellular matrix interactions and in its ability to act as an intramembrane ligand for ERBB2. Plays an important role in cell proliferation and differentiation of epithelial cells by inducing specific phosphorylation of ERBB2. The MUC4-ERBB2 complex causes site-specific phosphorylation of the ERBB2 'Tyr-1248'. In polarized epithelilal cells segragates ERBB2 and other ERBB receptors and prevents ERBB2 from acting as a coreceptor. The interaction with ERBB2 leads to enhanced expression of CDKN1B. The formation of a MUC4-ERBB2-ERBB3-NRG1 complex leads to down-regulation of CDKN1B, resulting in repression of apoptosis and stimulation of proliferation.

Molekulargewicht: 231518

UniProt: Q99102

Pathways: Regulation of Leukocyte Mediated Immunity