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MUC4 Antikörper (N-Term)

Dieses Anti-MUC4-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von MUC4 in WB. Geeignet für Human.
Produktnummer ABIN6242467

Kurzübersicht für MUC4 Antikörper (N-Term) (ABIN6242467)

Target

Alle MUC4 Antikörper anzeigen
MUC4 (Mucin 4, Cell Surface Associated (MUC4))

Reaktivität

  • 67
  • 15
  • 6
  • 1
Human

Wirt

  • 36
  • 36
Kaninchen

Klonalität

  • 45
  • 27
Polyklonal

Konjugat

  • 45
  • 7
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Dieser MUC4 Antikörper ist unkonjugiert

Applikation

  • 45
  • 36
  • 20
  • 16
  • 12
  • 10
  • 6
  • 4
  • 2
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
Western Blotting (WB)

Klon

RB49957
  • Bindungsspezifität

    • 24
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 529-560, N-Term

    Aufreinigung

    This antibody is purified through a protein A column, followed by peptide affinity purification.

    Immunogen

    This MUC4(Mucin-4 alpha chain) antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 529-560 amino acids from the N-terminal region of human MUC4(Mucin-4 alpha chain).

    Isotyp

    IgG
  • Applikationshinweise

    WB: 1:1000

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Liquid

    Buffer

    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

    Konservierungsmittel

    Sodium azide

    Vorsichtsmaßnahmen

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Lagerung

    4 °C,-20 °C

    Haltbarkeit

    6 months
  • Target

    MUC4 (Mucin 4, Cell Surface Associated (MUC4))

    Andere Bezeichnung

    MUC4(Mucin-4 alpha chain)

    Hintergrund

    May play a role in tumor progression. Ability to promote tumor growth may be mainly due to repression of apoptosis as opposed to proliferation. Has anti-adhesive properties. Seems to alter cellular behavior through both anti-adhesive effects on cell-cell and cell-extracellular matrix interactions and in its ability to act as an intramembrane ligand for ERBB2. Plays an important role in cell proliferation and differentiation of epithelial cells by inducing specific phosphorylation of ERBB2. The MUC4-ERBB2 complex causes site-specific phosphorylation of the ERBB2 'Tyr-1248'. In polarized epithelilal cells segragates ERBB2 and other ERBB receptors and prevents ERBB2 from acting as a coreceptor. The interaction with ERBB2 leads to enhanced expression of CDKN1B. The formation of a MUC4-ERBB2-ERBB3-NRG1 complex leads to down-regulation of CDKN1B, resulting in repression of apoptosis and stimulation of proliferation.

    Molekulargewicht

    231518

    UniProt

    Q99102

    Pathways

    Regulation of Leukocyte Mediated Immunity
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