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DPPA3 Antikörper (C-Term)

Der Kaninchen Polyklonal Anti-DPPA3-Antikörper wurde für WB validiert. Er ist geeignet, DPPA3 in Proben von Maus zu detektieren.
Produktnummer ABIN6242289

Kurzübersicht für DPPA3 Antikörper (C-Term) (ABIN6242289)

Target

Alle DPPA3 Antikörper anzeigen
DPPA3 (Developmental Pluripotency Associated 3 (DPPA3))

Reaktivität

  • 20
  • 11
  • 1
  • 1
Maus

Wirt

  • 21
  • 1
Kaninchen

Klonalität

  • 22
Polyklonal

Konjugat

  • 11
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Dieser DPPA3 Antikörper ist unkonjugiert

Applikation

  • 9
  • 7
  • 4
  • 4
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
Western Blotting (WB)

Klon

RB51138
  • Bindungsspezifität

    • 8
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 134-170, C-Term

    Aufreinigung

    This antibody is purified through a protein A column, followed by peptide affinity purification.

    Immunogen

    This mouse Dppa3 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 134-170 amino acids from the C-terminal region of mouse Dppa3.

    Isotyp

    Ig Fraction
  • Applikationshinweise

    WB: 1:1000

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Liquid

    Buffer

    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

    Konservierungsmittel

    Sodium azide

    Vorsichtsmaßnahmen

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Lagerung

    4 °C,-20 °C

    Haltbarkeit

    6 months
  • Target

    DPPA3 (Developmental Pluripotency Associated 3 (DPPA3))

    Andere Bezeichnung

    Dppa3

    Hintergrund

    Primordial germ cell (PGCs)-specific protein involved in epigenetic chromatin reprogramming in the zygote following fertilization. In zygotes, DNA demethylation occurs selectively in the paternal pronucleus before the first cell division, while the adjacent maternal pronucleus and certain paternally-imprinted loci are protected from this process. Participates in protection of DNA methylation in the maternal pronucleus by preventing conversion of 5mC to 5hmC: specifically recognizes and binds histone H3 dimethylated at 'Lys-9' (H3K9me2) on maternal genome, and protects maternal genome from TET3-mediated conversion to 5hmC and subsequent DNA demethylation. Does not bind paternal chromatin, which is mainly packed into protamine and does not contain much H3K9me2 mark. Also protects imprinted loci that are marked with H3K9me2 in mature sperm from DNA demethylation in early embryogenesis. May be important for the totipotent/pluripotent states continuing through preimplantation development. Also involved in chromatin condensation in oocytogenesis.

    Molekulargewicht

    17670

    UniProt

    Q8QZY3
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