CHD5 Antikörper (AA 64-98)

Produktnummer ABIN6242241

Der Kaninchen Polyklonal Anti-CHD5-Antikörper wurde für WB validiert. Er ist geeignet, CHD5 in Proben von Human zu detektieren.

Kurzübersicht für CHD5 Antikörper (AA 64-98) (ABIN6242241)

Target: CHD5 (Chromodomain Helicase DNA Binding Protein 5 (CHD5))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CHD5 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Klon: RB54755

Produktdetails anti-CHD5 Antikörper

Bindungsspezifität: AA 64-98

Aufreinigung: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This CHD5 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 64-98 amino acids from human CHD5.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: WB: 1:2000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Haltbarkeit: 6 months

Details zu CHD5

Target: CHD5 (Chromodomain Helicase DNA Binding Protein 5 (CHD5))

Andere Bezeichnung: CHD5

Hintergrund: Chromatin-remodeling protein that binds DNA through histones and regulates gene transcription. May specifically recognize and bind trimethylated 'Lys-27' (H3K27me3) and non- methylated 'Lys-4' of histone H3. Plays a role in the development of the nervous system by activating the expression of genes promoting neuron terminal differentiation. In parallel, it may also positively regulate the trimethylation of histone H3 at 'Lys- 27' thereby specifically repressing genes that promote the differentiation into non-neuronal cell lineages. Tumor suppressor, it regulates the expression of genes involved in cell proliferation and differentiation. Downstream activated genes may include CDKN2A that positively regulates the p53/TP53 pathway, which in turn, prevents cell proliferation. In spermatogenesis, it probably regulates histone hyperacetylation and the replacement of histones by transition proteins in chromatin, a crucial step in the condensation of spermatid chromatin and the production of functional spermatozoa.

Molekulargewicht: 223050

UniProt: Q8TDI0