ANKRD15 Antikörper

Produktnummer ABIN6242162

Dieses Maus Monoklonal-Antikörper erkennt spezifisch ANKRD15 in WB und IHC (p). Er zeigt eine Reaktivität gegenüber Human.

Kurzübersicht für ANKRD15 Antikörper (ABIN6242162)

Target: ANKRD15 (Ankyrin Repeat Domain 15 (ANKRD15))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser ANKRD15 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Klon: 1773CT634-49-61

Produktdetails anti-ANKRD15 Antikörper

Aufreinigung: This antibody is purified through a protein G column, followed by dialysis against PBS.

Immunogen: This KANK1 antibody is generated from a mouse immunized with a recombinant protein of human KANK1.

Isotyp: IgG1 kappa

Anwendungsinformationen

Applikationshinweise: WB: 1:2000. IHC-P: 1:25

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified monoclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Haltbarkeit: 6 months

Details zu ANKRD15

Target: ANKRD15 (Ankyrin Repeat Domain 15 (ANKRD15))

Andere Bezeichnung: KANK1

Hintergrund: Involved in the control of cytoskeleton formation by regulating actin polymerization. Inhibits actin fiber formation and cell migration. Inhibits RhoA activity, the function involves phosphorylation through PI3K/Akt signaling and may depend on the competetive interaction with 14-3-3 adapter proteins to sequester them from active complexes. Inhibits the formation of lamellipodia but not of filopodia, the function may depend on the competetive interaction with BAIAP2 to block its association with activated RAC1. Inhibits fibronectin-mediated cell spreading, the function is partially mediated by BAIAP2. Inhibits neurite outgrowth. Involved in the establishment and persistence of cell polarity during directed cell movement in wound healing. In the nucleus, is involved in beta-catenin-dependent activation of transcription. Potential tumor suppressor for renal cell carcinoma.

Molekulargewicht: 147289

UniProt: Q14678

Pathways: Regulation of Actin Filament Polymerization