HGS Antikörper
Kurzübersicht für HGS Antikörper (ABIN6241891)
Target
Alle HGS Antikörper anzeigenReaktivität
Wirt
Klonalität
Konjugat
Applikation
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Immunogen
- Synthetic Peptide
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anti-Hepatocyte Growth Factor-Regulated tyrosine Kinase Substrate (HGS) (AA 513-612) antibody
HGS Reaktivität: Human WB, ELISA, IF, RNAi Wirt: Maus Monoclonal 6D11 unconjugated
anti-Hepatocyte Growth Factor-Regulated tyrosine Kinase Substrate (HGS) (C-Term) antibodyHGS Reaktivität: Human WB, IF, IHC (p), ICC Wirt: Kaninchen Polyclonal unconjugated
anti-Hepatocyte Growth Factor-Regulated tyrosine Kinase Substrate (HGS) (Internal Region) antibodyHGS Reaktivität: Human, Maus, Ratte WB, ELISA, IHC, IF, ICC Wirt: Kaninchen Polyclonal unconjugated
anti-Hepatocyte Growth Factor-Regulated tyrosine Kinase Substrate (HGS) (Internal Region) antibodyHGS Reaktivität: Human, Maus, Ratte WB, IF, IHC (p), EIA Wirt: Kaninchen Polyclonal unconjugated
anti-Hepatocyte Growth Factor-Regulated tyrosine Kinase Substrate (HGS) (AA 548-777) antibodyHGS Reaktivität: Human WB, IF Wirt: Kaninchen Polyclonal unconjugated
anti-Hepatocyte Growth Factor-Regulated tyrosine Kinase Substrate (HGS) (AA 513-612) antibodyHGS Reaktivität: Human WB, ELISA Wirt: Maus Polyclonal unconjugated
anti-Hepatocyte Growth Factor-Regulated tyrosine Kinase Substrate (HGS) (AA 451-500) antibodyHGS Reaktivität: Human, Maus, Ratte WB, ELISA, IHC, IF, IHC (p) Wirt: Kaninchen Polyclonal unconjugated
anti-Hepatocyte Growth Factor-Regulated tyrosine Kinase Substrate (HGS) (AA 301-350) antibodyHGS Reaktivität: Human, Maus, Ratte WB, ELISA, IHC, IF, IHC (p) Wirt: Kaninchen Polyclonal unconjugated
anti-Hepatocyte Growth Factor-Regulated tyrosine Kinase Substrate (HGS) (AA 256-286), (N-Term) antibodyHGS Reaktivität: Human, Maus WB, IHC (p) Wirt: Kaninchen Polyclonal RB4400 unconjugated
anti-Hepatocyte Growth Factor-Regulated tyrosine Kinase Substrate (HGS) antibodyHGS Reaktivität: Human WB, IF Wirt: Maus Monoclonal 3H7 unconjugated
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Applikationshinweise
- IF: 1:100. WB: 1:1000. IHC: 1:50-1:100
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Beschränkungen
- Nur für Forschungszwecke einsetzbar
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Format
- Liquid
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Lagerung
- 4 °C,-20 °C
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- HGS (Hepatocyte Growth Factor-Regulated tyrosine Kinase Substrate (HGS))
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Andere Bezeichnung
- HGS
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Hintergrund
- Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin-coated regions. Involved in down- regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes. May contribute to the efficient recruitment of SMADs to the activin receptor complex. Involved in receptor recycling via its association with the CART complex, a multiprotein complex required for efficient transferrin receptor recycling but not for EGFR degradation.
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UniProt
- O14964
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Pathways
- EGFR Signaling Pathway, CXCR4-mediated Signaling Events, Synaptic Vesicle Exocytosis, EGFR Downregulation
Target
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