JMJD6 Antikörper (N-Term)

Produktnummer ABIN6241759

Dieses Anti-JMJD6-Antikörper ist ein Maus Monoklonal-Antikörper zur Detektion von JMJD6 in WB und ICC. Geeignet für Human.

Kurzübersicht für JMJD6 Antikörper (N-Term) (ABIN6241759)

Target: JMJD6 (Jumonji Domain Containing 6 (JMJD6))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser JMJD6 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunocytochemistry (ICC)

Produktdetails anti-JMJD6 Antikörper

Bindungsspezifität: N-Term

Immunogen: Recombinant Protein

Anwendungsinformationen

Applikationshinweise: WB: 1:1000. ICC: 1:200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Lagerung: 4 °C,-20 °C

Details zu JMJD6

Target: JMJD6 (Jumonji Domain Containing 6 (JMJD6))

Andere Bezeichnung: JMJD6

Hintergrund: Dioxygenase that can both act as a histone arginine demethylase and a lysyl-hydroxylase. Acts as a lysyl-hydroxylase that catalyzes 5-hydroxylation on specific lysine residues of target proteins such as U2AF2/U2AF65 and LUC7L2. Acts as a regulator of RNA splicing by mediating 5-hydroxylation of U2AF2/U2AF65, affecting the pre-mRNA splicing activity of U2AF2/U2AF65. In addition to peptidyl-lysine 5-dioxygenase activity, may act as an RNA hydroxylase, as suggested by its ability to bind single strand RNA. Also acts as an arginine demethylase which demethylates histone H3 at 'Arg-2' (H3R2me) and histone H4 at 'Arg-3' (H4R3me), thereby playing a role in histone code. However, histone arginine demethylation may not constitute the primary activity in vivo. Has no histone lysine demethylase activity. Required for differentiation of multiple organs during embryogenesis. Acts as a key regulator of hematopoietic differentiation: required for angiogenic sprouting by regulating the pre-mRNA splicing activity of U2AF2/U2AF65. Seems to be necessary for the regulation of macrophage cytokine responses.

UniProt: Q6NYC1