Protein Phosphatase 4C Antikörper

Produktnummer ABIN6241238

Dieser Maus Monoklonal Antikörper detektiert spezifisch Protein Phosphatase 4C in WB, ICC und IHC. Es zeigt Reaktivität gegenüber Proben von Human.

Kurzübersicht für Protein Phosphatase 4C Antikörper (ABIN6241238)

Target: Protein Phosphatase 4C

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Unkonjugiert

Applikation: Western Blotting (WB), Immunocytochemistry (ICC), Immunohistochemistry (IHC)

Produktdetails

Immunogen: Recombinant Protein

Anwendungsinformationen

Applikationshinweise: WB: 1:200. IHC: 1:100. ICC: 1:200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Lagerung: 4 °C,-20 °C

Antigendetails

Target: Protein Phosphatase 4C

Hintergrund: Protein phosphatase that is involved in many processes such as microtubule organization at centrosomes, maturation of spliceosomal snRNPs, apoptosis, DNA repair, tumor necrosis factor (TNF)-alpha signaling, activation of c-Jun N-terminal kinase MAPK8, regulation of histone acetylation, DNA damage checkpoint signaling, NF-kappa-B activation and cell migration. The PPP4C- PPP4R1 PP4 complex may play a role in dephosphorylation and regulation of HDAC3. The PPP4C-PPP4R2-PPP4R3A PP4 complex specifically dephosphorylates H2AFX phosphorylated on Ser-140 (gamma-H2AFX) generated during DNA replication and required for DNA double strand break repair. Dephosphorylates NDEL1 at CDK1 phosphorylation sites and negatively regulates CDK1 activity in interphase (By similarity). In response to DNA damage, catalyzes RPA2 dephosphorylation, an essential step for DNA repair since it allows the efficient RPA2-mediated recruitment of RAD51 to chromatin.

UniProt: P60510