LC3A / LC3B Antikörper
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- Target
- LC3A / LC3B
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Reaktivität
- Human, Ratte
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Wirt
- Maus
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Klonalität
- Monoklonal
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Konjugat
- Unkonjugiert
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Applikation
- Western Blotting (WB)
- Klon
- 3E9-E5-C9
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anti-LC3A / LC3B antibody
Reaktivität: Maus, Human, Ratte WB, IHC Wirt: Kaninchen Polyclonal unconjugated
anti-LC3A / LC3B (AA 31-121) antibodyReaktivität: Maus IF (cc), IF (p), ELISA, IHC (fro), IHC (p), ICC Wirt: Kaninchen Polyclonal unconjugated
anti-LC3A / LC3B antibodyReaktivität: Maus, Human, Ratte IF Wirt: Kaninchen Polyclonal unconjugated
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- Applikationshinweise
- WB: 1:1000
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Lagerung
- 4 °C,-20 °C
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- Target
- LC3A / LC3B
- Andere Bezeichnung
- LC3A/B
- Hintergrund
- LC3A:Ubiquitin-like modifier involved in formation of autophagosomal vacuoles (autophagosomes) (PubMed:20713600, PubMed:24290141). Whereas LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation (PubMed:20713600). LC3B:Ubiquitin-like modifier involved in formation of autophagosomal vacuoles (autophagosomes). Plays a role in mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Whereas LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation. Promotes primary ciliogenesis by removing OFD1 from centriolar satellites via the autophagic pathway.
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