TGF-beta Antikörper (CF®405S)

Produktnummer ABIN6180682

Produktdetails anti-TGF-beta Antikörper (CF®405S)

Target: TGF-beta (TGFb)

Reaktivität: Human, Maus, Ratte, Rind (Kuh), Hund, Hamster, Affe

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser TGF-beta Antikörper ist konjugiert mit CF®405S

Applikation: Neutralization (Neut), Functional Studies (Func)

Verwendungszweck: Mouse Monoclonal anti-TGF-beta (1D11.16.8), CF405S Conjugate

Produktmerkmale: This MAb recognizes TGF beta 1, 2 and 3. Three TGF? ?s have been identified in mammals. TGF? ?1, TGF? ?2 and TGF? ?3 are each synthesized as precursor proteins that are very similar in that each is cleaved to yield a 112 amino acid polypeptide that remains associated with the latent portion of the molecules. Biologically active TGF? ? requires dimerization of the monomers (usually homodimers) and release of the latent peptide portion. Overall, the mature region of the TGF? ?3 protein has approximately 80 % identity to the mature region of both TGF? ?1 and TGF? ?2. However, the NH2 terminals or precursor regions of their molecules share only 27 % sequence identity. TGF? ?'s inhibit the growth of epithelial cells and stimulate the growth of mesenchymal cells. Primary antibodies are available purified, or with a selection of fluorescent CF® dyes and other labels. CF® dyes offer exceptional brightness and photostability. See the < a href="https://biotium.com/wp-content/uploads/2013/07/CF-dye-selection-guide.pdf" target="_blank" rel="noopener">CF® Dye Selection Guide for more information. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Immunogen: Bovine TGF-beta2 protein

Klon: 1D11-16-8

Isotyp: IgG1 kappa

Anwendungsinformationen

Applikationshinweise: Cytokine neutralization or functional assay, order Ab without BSA/azideOptimal dilution for a specific application should be determined by user

Kommentare:

Salivary gland carcinoma

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 100 μg/mL

Buffer: PBS/0.1 % BSA/0.05 % azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Protect from light

Details zu TGF-beta

Target: TGF-beta (TGFb)

Andere Bezeichnung: TGF-beta (TGFb Produkte)

Synonyme: CED antikoerper, DPD1 antikoerper, LAP antikoerper, TGFB antikoerper, TGFbeta antikoerper, TGF-beta antikoerper, TGF-BETA-1 antikoerper, TGF-beta1 antikoerper, TGFbeta1 antikoerper, Tgfb antikoerper, Tgfb-1 antikoerper, transforming growth factor beta 1 antikoerper, transforming growth factor beta-1 antikoerper, transforming growth factor, beta 1 antikoerper, TGFB1 antikoerper, Tgfb1 antikoerper

Hintergrund: GP40, Leu9, p41, T-cell leukemia antigen, T-cell surface antigen Leu-9, Tp40, TP41

Molekulargewicht: ~13 kDa

Gen-ID: 7040, 7042, 7043

Pathways: EGFR Signaling Pathway, Cellular Response to Molecule of Bacterial Origin, Stem Cell Maintenance, Glycosaminoglycan Metabolic Process, Regulation of Muscle Cell Differentiation, Cell-Cell Junction Organization, Ribonucleoside Biosynthetic Process, Skeletal Muscle Fiber Development, Regulation of Carbohydrate Metabolic Process, Protein targeting to Nucleus