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Rekombinanter ANO1 Antikörper

ANO1 Reaktivität: Human IF, FACS, IHC Wirt: Kaninchen Monoclonal DG1-1487R unconjugated Recombinant Antibody
Produktnummer ABIN6173155
  • Target Alle ANO1 Antikörper anzeigen
    ANO1 (Anoctamin 1, Calcium Activated Chloride Channel (ANO1))
    Antikörpertyp
    Recombinant Antibody
    Reaktivität
    • 127
    • 31
    • 29
    • 7
    • 7
    • 5
    • 3
    • 2
    • 2
    • 1
    Human
    Wirt
    • 81
    • 50
    Kaninchen
    Klonalität
    • 68
    • 63
    Monoklonal
    Konjugat
    • 57
    • 13
    • 9
    • 7
    • 5
    • 4
    • 4
    • 4
    • 4
    • 4
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser ANO1 Antikörper ist unkonjugiert
    Applikation
    • 63
    • 51
    • 42
    • 36
    • 35
    • 20
    • 18
    • 13
    • 13
    • 9
    • 4
    • 3
    • 2
    • 1
    • 1
    Immunofluorescence (IF), Flow Cytometry (FACS), Immunohistochemistry (IHC)
    Verwendungszweck
    Recombinant Rabbit Monoclonal anti-DOG-1 / TMEM16A (DG1/1487R), Purified, with BSA
    Produktmerkmale
    Expression of DOG-1 protein is elevated in the gastrointestinal stromal tumors (GIST s), c-kit signaling-driven mesenchymal tumors of the GI tract. DOG-1 is rarely expressed in other soft tissue tumors, which, due to appearance, may be difficult to diagnose. Immunoreactivity for DOG-1 has been reported in 97.8 percent of scorable GIST s, including all c-kit negative GIST s. Overexpression of DOG-1 has been suggested to aid in the identification of GISTs, including Platelet-Derived Growth Factor Receptor Alpha mutants that fail to express c-kit antigen. The overall sensitivity of DOG1 and c-kit in GIST s is nearly identical: 94.4 % vs. 94.7 %. Primary antibodies are available purified, or with a selection of fluorescent CF® dyes and other labels. CF® dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.
    Aufreinigung
    Purified
    Immunogen
    Recombinant full-length human DOG-1 protein
    Klon
    DG1-1487R
    Isotyp
    IgG kappa
    Top Product
    Discover our top product ANO1 Primärantikörper
  • Applikationshinweise
    Immunohistology (formalin) 0.25-0.5 μg/mL
    • Staining of formalin-fixed tissues requires boiling tissue sections in 10 mM citrate buffer,  pH 6.0, for 10-20 min followed by cooling at RT for 20 min
    • Immunofluorescence 0.5-1 μg/mL
    • Flow Cytometry 0.5-1 μg/million cells/0.1 mL
    • Optimal dilution for a specific application should be determined by user
    Kommentare

    Gastrointestinal Stromal Tumor (GIST) or testicular germ cell tumor. Melanocytes in the basal layer of the epidermis and mast cells in the dermis of normal skin.

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    200 μg/mL
    Buffer
    PBS/0.05 % BSA/0.05 % azide
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
  • Target
    ANO1 (Anoctamin 1, Calcium Activated Chloride Channel (ANO1))
    Andere Bezeichnung
    DOG-1 / TMEM16A (ANO1 Produkte)
    Synonyme
    DOG1 antikoerper, ORAOV2 antikoerper, TAOS2 antikoerper, TMEM16A antikoerper, Tmem16a antikoerper, anoctamin 1 antikoerper, anoctamin 1, calcium activated chloride channel antikoerper, Ano1 antikoerper, ANO1 antikoerper
    Hintergrund
    Anoctamin 1, Calcium Activated Chloride Channel, Discovered On Gastrointestinal Stromal Tumors Protein 1, TAOS2, ORAOV2, TMEM16A
    Molekulargewicht
    ~114 kDa
    Gen-ID
    55107, 503074
    UniProt
    Q5XXA6
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