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Rekombinanter ANO1 Antikörper

Der Kaninchen Monoklonal Anti-ANO1-Antikörper wurde für IHC, IF und FACS validiert. Er ist geeignet, ANO1 in Proben von Human zu detektieren.
Produktnummer ABIN6173155

Kurzübersicht für Rekombinanter ANO1 Antikörper (ABIN6173155)

Target

Alle ANO1 Antikörper anzeigen
ANO1 (Anoctamin 1, Calcium Activated Chloride Channel (ANO1))

Antikörpertyp

Recombinant Antibody

Reaktivität

  • 167
  • 36
  • 26
  • 6
  • 6
  • 4
  • 3
  • 2
  • 2
  • 1
  • 1
Human

Wirt

  • 106
  • 66
Kaninchen

Klonalität

  • 101
  • 70
  • 1
Monoklonal

Konjugat

  • 67
  • 15
  • 10
  • 8
  • 8
  • 7
  • 7
  • 7
  • 7
  • 7
  • 6
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Dieser ANO1 Antikörper ist unkonjugiert

Applikation

  • 78
  • 59
  • 49
  • 44
  • 36
  • 32
  • 20
  • 16
  • 13
  • 13
  • 10
  • 4
  • 3
  • 3
  • 1
  • 1
  • 1
  • 1
Immunohistochemistry (IHC), Immunofluorescence (IF), Flow Cytometry (FACS)

Klon

DG1-1487R
  • Verwendungszweck

    Recombinant Rabbit Monoclonal anti-DOG-1 / TMEM16A (DG1/1487R), Purified, with BSA

    Produktmerkmale

    Expression of DOG-1 protein is elevated in the gastrointestinal stromal tumors (GIST s), c-kit signaling-driven mesenchymal tumors of the GI tract. DOG-1 is rarely expressed in other soft tissue tumors, which, due to appearance, may be difficult to diagnose. Immunoreactivity for DOG-1 has been reported in 97.8 percent of scorable GIST s, including all c-kit negative GIST s. Overexpression of DOG-1 has been suggested to aid in the identification of GISTs, including Platelet-Derived Growth Factor Receptor Alpha mutants that fail to express c-kit antigen. The overall sensitivity of DOG1 and c-kit in GIST s is nearly identical: 94.4 % vs. 94.7 %. Primary antibodies are available purified, or with a selection of fluorescent CF® dyes and other labels. CF® dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

    Aufreinigung

    Purified

    Immunogen

    Recombinant full-length human DOG-1 protein

    Isotyp

    IgG kappa
  • Applikationshinweise

    Immunohistology (formalin) 0.25-0.5 μg/mL
    • Staining of formalin-fixed tissues requires boiling tissue sections in 10 mM citrate buffer,  pH 6.0, for 10-20 min followed by cooling at RT for 20 min
    • Immunofluorescence 0.5-1 μg/mL
    • Flow Cytometry 0.5-1 μg/million cells/0.1 mL
    • Optimal dilution for a specific application should be determined by user

    Kommentare

    Gastrointestinal Stromal Tumor (GIST) or testicular germ cell tumor. Melanocytes in the basal layer of the epidermis and mast cells in the dermis of normal skin.

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Liquid

    Konzentration

    200 μg/mL

    Buffer

    PBS/0.05 % BSA/0.05 % azide

    Konservierungsmittel

    Sodium azide

    Vorsichtsmaßnahmen

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
  • Target

    ANO1 (Anoctamin 1, Calcium Activated Chloride Channel (ANO1))

    Andere Bezeichnung

    DOG-1 / TMEM16A

    Hintergrund

    Anoctamin 1, Calcium Activated Chloride Channel, Discovered On Gastrointestinal Stromal Tumors Protein 1, TAOS2, ORAOV2, TMEM16A

    Molekulargewicht

    ~114 kDa

    Gen-ID

    55107, 503074

    UniProt

    Q5XXA6
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