CD7 Antikörper (Biotin)

Produktnummer ABIN6160246

Der Maus Monoklonal Anti-CD7-Antikörper wurde für FACS und IF validiert. Er ist geeignet, CD7 in Proben von Human, Meerschweinchen und Schwein zu detektieren.

Kurzübersicht für CD7 Antikörper (Biotin) (ABIN6160246)

Target: CD7

Reaktivität: Human, Meerschweinchen, Schwein

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser CD7 Antikörper ist konjugiert mit Biotin

Applikation: Flow Cytometry (FACS), Immunofluorescence (IF)

Klon: B-F12

Produktdetails anti-CD7 Antikörper (Biotin)

Verwendungszweck: Mouse Monoclonal anti-CD7 (B-F12), Biotin Conjugate

Produktmerkmale: This antibody recognizes a protein of 40 kDa, identified as CD7 (also known as gp40, Leu9). CD7 is a member of the immunoglobulin gene superfamily. Its N-terminal amino acids 1-107 are highly homologous to Ig kappa-L chains whereas the carboxyl-terminal region of the extracellular domain is proline-rich and has been postulated to form a stalk from which the Ig domain projects. CD7 is expressed on the majority of immature and mature T-lymphocytes, and T cell leukemia. It is also found on natural killer cells, a small subpopulation of normal B cells and on malignant B cells. Cross-linking surface CD7 positively modulates T cell and NK cell activity as measured by calcium fluxes, expression of adhesion molecules, cytokine secretion and proliferation. CD7 associates directly with phosphoinositol 3'-kinase. CD7 ligation induces production of D-3 phosphoinositides and tyrosine phosphorylation. Primary antibodies are available purified, or with a selection of fluorescent CF® dyes and other labels. CF® dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Immunogen: Chronic Lymphoid Leukemia cells (CLL)

Isotyp: IgG2a kappa

Anwendungsinformationen

Applikationshinweise: Immunofluorescence 0.5-1 μg/mL

• Flow Cytometry 0.5-1 μg/million cells/0.1 mL
• Optimal dilution for a specific application should be determined by user

Kommentare:

Jurkat, HUT-78, Molt-4, CEM cells, or human peripheral blood lymphocytes. Lymph node and tonsil.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 100 μg/mL

Buffer: PBS/0.1 % BSA/0.05 % azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Details zu CD7

Target: CD7

Andere Bezeichnung: CD7

Hintergrund: GP40, Leu9, p41, T-cell leukemia antigen, T-cell surface antigen Leu-9, Tp40, TP41

Molekulargewicht: 40 kDa

Gen-ID: 924, 186820

UniProt: P09564

Pathways: Cell-Cell Junction Organization