PDCD10 Antikörper (N-Term)

Produktnummer ABIN616008

Der Kaninchen Polyklonal Anti-PDCD10-Antikörper wurde für WB und IF validiert. Er ist geeignet, PDCD10 in Proben von Human zu detektieren.

Kurzübersicht für PDCD10 Antikörper (N-Term) (ABIN616008)

Target: PDCD10 (Programmed Cell Death 10 (PDCD10))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PDCD10 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF)

Produktdetails anti-PDCD10 Antikörper

Bindungsspezifität: AA 1-212, N-Term

Spezifität: This antibody will detect recombinant Human CCM-3 in Western Blot and native CCM-3 in Immunohistochemistry.

Kreuzreaktivität (Details): Species reactivity (tested):Human.

Aufreinigung: Affinity Chromatography with Immobilized Protein A

Immunogen: Highly pure (> 95%) recombinant Human CCM3, amino acids Met1-Ala212 derived from E.coli

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Rekonstitution: Restore with sterile water to a concentration of 1.0 mg/mL.

Buffer: 5 mM PBS, pH 7.2 without preservatives or stabilizers

Konservierungsmittel: Without preservative

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: The lyophilized antibody can be stored at RT for up to 1 month, or desiccated at -20 °C for longer. Following reconstitution store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Details zu PDCD10

Target: PDCD10 (Programmed Cell Death 10 (PDCD10))

Andere Bezeichnung: PDCD10

Hintergrund: Cerebral cavernous malformations (CCMs) are sporadically acquired or inherited vascular lesions of the central nervous system consisting of clusters of dilated thin-walled blood vessels that predispose individuals to seizures and stroke. Mutations in CCM1, CCM2, or CCM3 lead to cerebral cavernous malformations, one of the most common hereditary vascular diseases of the brain. Endothelial cells within these lesions are the main disease compartments. Here, we show that adenoviral CCM3 expression inhibits endothelial cell migration, proliferation, and tube formation while down regulation of endogenous CCM3 results in increased formation of tube-like structures. Adenoviral CCM3 expression does not induce apoptosis under normal endothelial cell culture conditions but protects endothelial cells from staurosporine-induced cell death. Tyrosine kinase activity profiling suggests that CCM3 supports PDPK-1/Akt-mediated endothelial cell quiescence and survival (Schleider et al, Neurogenetics 12, 2011).Synonyms: CCM3, Cerebral cavernous malformations 3 protein, Programmed cell death protein 10, TF-1 cell apoptosis-related protein 15, TFAR15

Gen-ID: 11235

NCBI Accession: NP_009148

UniProt: Q9BUL8