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KRIT1 Antikörper (N-Term)

KRIT1 Reaktivität: Human WB, IF Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN616004
  • Target Alle KRIT1 Antikörper anzeigen
    KRIT1 (KRIT1, Ankyrin Repeat Containing (KRIT1))
    Bindungsspezifität
    • 15
    • 6
    • 6
    • 6
    • 4
    • 3
    • 2
    • 1
    • 1
    • 1
    AA 1-736, N-Term
    Reaktivität
    • 28
    • 21
    • 6
    Human
    Wirt
    • 39
    • 4
    Kaninchen
    Klonalität
    • 39
    • 4
    Polyklonal
    Konjugat
    • 15
    • 4
    • 4
    • 4
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser KRIT1 Antikörper ist unkonjugiert
    Applikation
    • 36
    • 22
    • 13
    • 13
    • 3
    • 3
    • 3
    • 2
    • 1
    Western Blotting (WB), Immunofluorescence (IF)
    Spezifität
    This antibody is anti-His depleated. It detects KRIT1 / CCM1.
    Kreuzreaktivität (Details)
    Species reactivity (tested):Human.
    Aufreinigung
    Protein A Chromatography
    Immunogen
    Highly pure (>95%) recombinant Human CCM-1 (Met1-Ser736) derived from E. coli fused to a C-teminal His-tag (6 x His) (Cat.-No AR26002PU-N)
    Isotyp
    IgG
    Top Product
    Discover our top product KRIT1 Primärantikörper
  • Applikationshinweise
    Optimal working dilution should be determined by the investigator.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Rekonstitution
    Restore in sterile water to a concentration of 0.1-1.0 mg/mL. Centrifuge vial prior to opening.
    Buffer
    5 mM PBS, pH 7.2
    Handhabung
    Avoid repeated freezing and thawing.
    Lagerung
    4 °C/-20 °C
    Informationen zur Lagerung
    Prior to reconstitution store at 2-8 °C. Following reconstitution store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
  • Target
    KRIT1 (KRIT1, Ankyrin Repeat Containing (KRIT1))
    Andere Bezeichnung
    KRIT1 / CCM1 (KRIT1 Produkte)
    Synonyme
    CAM antikoerper, CCM1 antikoerper, 2010007K12Rik antikoerper, A630036P20Rik antikoerper, AA432855 antikoerper, AI450393 antikoerper, AI643869 antikoerper, BB155247 antikoerper, BB235701 antikoerper, Ccm1 antikoerper, RGD1305929 antikoerper, krit1 antikoerper, fb36f07 antikoerper, san antikoerper, santa antikoerper, wu:fb36f07 antikoerper, zgc:63585 antikoerper, KRIT1, ankyrin repeat containing antikoerper, KRIT1 antikoerper, Krit1 antikoerper, krit1 antikoerper
    Hintergrund
    Cerebral Cavernous Malformations (CCM) are frequent vascular abnormalities caused by mutations in one of the CCM genes. CCM-1 (also known as KRIT1) stabilizes endothelial junctions and is essential for vascular morphogenesis in mouse embryos. However, cellular functions of CCM-1 during the early steps of the CCM pathogenesis remain unknown. It was shown that CCM-1 represents an antiangiogenic protein to keep the human endothelium quiescent. CCM-1 inhibits endothelial proliferation, apoptosis, migration, lumen formation, and sprouting angiogenesis in primary human endothelial cells. CCM-1 strongly induces DLL4-NOTCH signaling, which promotes AKT phosphorylation but reduces phosphorylation of the mitogen-activated protein kinase ERK. Consistently, blocking of NOTCH activity alleviates CCM-1 effects. ERK phosphorylation is increased in human CCM lesions. Transplantation of CCM-1-silenced human endothelial cells into SCID mice recapitulates hallmarks of the CCM pathology and serves as a unique CCM model system.Synonyms: Krev interaction trapped 1
    Gen-ID
    889
    NCBI Accession
    NP_004903
    UniProt
    O00522
    Pathways
    Cell RedoxHomeostasis
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