CCBE1 Antikörper (AA 35-406)

Produktnummer ABIN616002

Produktdetails anti-CCBE1 Antikörper

Target: CCBE1 (Collagen and Calcium Binding EGF Domains 1 (CCBE1))

Bindungsspezifität: AA 35-406

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CCBE1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF)

Spezifität: This antibody detects CCBE1.

Kreuzreaktivität (Details): Species reactivity (tested):Human

Aufreinigung: Protein-A chromatography

Immunogen: Highly pure (>95%) recombinant human ccbe1 (Tyr35-Pro406) derived from Sf9 insect cells

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Rekonstitution: Centrifuge vial prior to opening. Reconstitute in sterile water to a concentration of 0.1-1.0 mg/mL.

Buffer: PBS, pH 7.2

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: The lyophilized antibody is stable at room temperature for up to 1 month. Following reconstitution antibody can be stored at 2-8 °C for up to two weeks or (in aliquots) at -20 °C for longer.

Details zu CCBE1

Target: CCBE1 (Collagen and Calcium Binding EGF Domains 1 (CCBE1))

Andere Bezeichnung: CCBE1 (CCBE1 Produkte)

Hintergrund: The lymphatic system comprises a vascular system separate from the cardiovascular system, essential for immune responses, fluid homeostasis and fat absorption. Lymphatic vessels develop in a complex process termed lymphangiogenesis that involves budding, migration and proliferation of lymphatic endothelial progenitor cells. A few genes, such as FLT4, FOXC2 and SOX18, are known to be critically involved in lymph vessel formation in humans. Lymphedema, lymphangiectasias, mental retardation and unusual facial characteristics define the autosomal recessive Hennekam syndrome. Homozygosity mapping identified a critical chromosomal region containing ccbe1, encoding Collagen and Calcium-Binding EGF-domain-1, a secreted protein which is required for embryonic lymphangiogenesis in zebrafish. ccbe1 is not expressed in endothelial cells of lymph vessels, and it may be a component of the extracellular matrix. In zebrafish, ccbe1 expression was observed along the earliest migration routes of endothelial cells that sprout from the posterior cardinal vein and migrate circuitously before developing into lymphatic vessels. ccbe1 might therefore be involved in guidance of these migrating cells.Synonyms: Collagen and calcium-binding EGF domain-containing protein 1, Full of fluid protein homolog, KIAA1983

Gen-ID: 147372

NCBI Accession: NP_597716

UniProt: Q6UXH8