HAP1 Antikörper (C-Term)

Produktnummer ABIN615992

Der Ziege Polyklonal anti-HAP1 Antikörper wird verwendet zum Nachweis von HAP1 in Proben von Maus und Ratte. Er wurde validiert für WB und EIA.

Kurzübersicht für HAP1 Antikörper (C-Term) (ABIN615992)

Target: HAP1 (Huntingtin Associated Protein 1 (HAP1))

Reaktivität: Maus, Ratte

Wirt: Ziege

Klonalität: Polyklonal

Konjugat: Dieser HAP1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Enzyme Immunoassay (EIA)

Produktdetails anti-HAP1 Antikörper

Bindungsspezifität: C-Term

Sequenz: C-QDAHSKRQQK QK

Spezifität: Recognizes Mouse Hap1

Kreuzreaktivität (Details): Species reactivity (expected):Rat.
Species reactivity (tested):Mouse.

Aufreinigung: Ammonium Sulphate Precipitation followed by antigen Affinity Chromatography using the immunizing peptide.

Immunogen: Peptide with sequence from the C Terminus of the protein sequence according to NP_034534.1. Genename: Hap1

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0.5 mg/mL

Buffer: Tris saline, pH 7.3 containing 0.02 % Sodium Azide as preservative and 0.5 % BSA as stabilizer.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Details zu HAP1

Target: HAP1 (Huntingtin Associated Protein 1 (HAP1))

Andere Bezeichnung: HAP1

Hintergrund: Huntington's disease (HD), a neurodegenerative disorder characterized by loss of striatal neurons, is caused by an expansion of a polyglutamine tract in the HD protein huntingtin. It is a progressive disorder that generally begins in middle age with abnormalities of movement, cognition, personality and mood. HAP-1 is highly expressed in brain and shown to mediate the neuropathology of HD. The human protein interacts with huntingtin, with two cytoskeletal proteins (dynactin and pericentriolar autoantigen protein 1), and with a hepatocyte growth factor-regulated tyrosine kinase substrate. The interactions with cytoskeletal proteins and a kinase substrate suggest a role for this protein in vesicular trafficking or organelle transport. Two transcripts encoding different isoforms have been identified but one is a nonsense-mediated decay (NMD) candidate.Synonyms: HAP-1, HAP2, HLP1, Huntingtin-associated protein 1, Neuroan 1

Gen-ID: 15114

NCBI Accession: NP_034534

UniProt: O35668

Pathways: Cell RedoxHomeostasis, Smooth Muscle Cell Migration, Positive Regulation of Response to DNA Damage Stimulus