Plakophilin 2 Antikörper (Internal Region)

Produktnummer ABIN615975

Der Ziege Polyklonal anti-Plakophilin 2 Antikörper (ABIN615975) detektiert spezifisch Plakophilin 2 in WB und EIA. Dieser Antikörper reagiert spezifisch mit Proben aus Human, Ratte, Maus, Hund und Rind (Kuh).

Kurzübersicht für Plakophilin 2 Antikörper (Internal Region) (ABIN615975)

Target: Plakophilin 2 (PKP2)

Reaktivität: Human, Ratte, Maus, Hund, Rind (Kuh)

Wirt: Ziege

Klonalität: Polyklonal

Konjugat: Dieser Plakophilin 2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Enzyme Immunoassay (EIA)

Produktdetails anti-Plakophilin 2 Antikörper

Bindungsspezifität: AA 125-139, Internal Region

Sequenz: C-RGTAQYSSQK SVEER

Spezifität: This antibody is expected to recognize both reported isoforms (NP_001005242.2, NP_004563.2).

Kreuzreaktivität (Details): Species reactivity (expected):Human, Canine (Dog), Cow.
Species reactivity (tested):Mouse and Rat.

Aufreinigung: Ammonium Sulphate Precipitation followed by antigen Affinity Chromatography using the immunizing peptide.

Immunogen: Peptide with sequence from the internal region of the protein sequence according to NP_001005242.2, NP_004563.2. Genename: PKP2

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0.5 mg/mL

Buffer: Tris saline, pH 7.3 containing 0.02 % Sodium Azide as preservative and 0.5 % BSA as stabilizer.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Details zu Plakophilin 2

Target: Plakophilin 2 (PKP2)

Andere Bezeichnung: Plakophilin-2

Hintergrund: Plakophilins 1, 2, 3 and 4 (PKP1-4) influence development and participate in linking cadherins to cytoskeletal intermediate filaments. Plakophilins 1-4 contain arm-repeat (armadillo) domains and localize to nuclei and cell desmosomes (cell-cell junctions found in suprabasal layers of stratifying epithelia that undergo mechanical stress). Plakophilin 1 mediates increases in desmosomal protein content, desmosome assembly and regulation of cell migration. Plakophilin 2 is important for desmosome assembly and is an essential morphogenic factor and architectural component of the heart. Plakophilin 4 is a component of desmosomal adhesion plaques that regulates junctional plaque organization and cadherin function.Synonyms: PKP2

Gen-ID: 5318

NCBI Accession: NP_004563

UniProt: Q99959

Pathways: Cell-Cell Junction Organization, SARS-CoV-2 Protein Interaktom, Phosphorylierungen bei SARS-CoV-2 Infektion