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HSPG Antikörper

HSPG Reaktivität: Human, Rind (Kuh), Maus, Fisch, Affe, Schwein IHC (p), IF, FACS, IHC (f) Wirt: Ratte Monoclonal A7L6 unconjugated
Produktnummer ABIN6159608
  • Target Alle HSPG Antikörper anzeigen
    HSPG (Heparan Sulphate Protoglycans (HSPG))
    Reaktivität
    • 17
    • 12
    • 11
    • 8
    • 8
    • 8
    • 2
    Human, Rind (Kuh), Maus, Fisch, Affe, Schwein
    Wirt
    • 11
    • 5
    • 4
    Ratte
    Klonalität
    • 16
    • 4
    Monoklonal
    Konjugat
    • 10
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser HSPG Antikörper ist unkonjugiert
    Applikation
    • 12
    • 11
    • 10
    • 9
    • 8
    • 8
    • 6
    • 5
    • 4
    • 2
    • 2
    • 1
    • 1
    Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF), Flow Cytometry (FACS), Immunohistochemistry (Formalin-fixed Sections) (IHC (f))
    Verwendungszweck
    Rat Monoclonal anti-Heparan Sulfate Proteoglycan (A7L6), Purified, BSA-free
    Produktmerkmale
    This MAb specifically precipitates heterogeneous material of high MW, identified as perlecan, a major heparan-sulfate proteoglycan (HSPG) within all basement membranes and cell surfaces. It does not cross-react with laminin, fibronectin, or dermatran sulfate proteoglycan. Because of perlecan s strategic location and ability to store and protect growth factors, it has been strongly implicated in the control of tumor cell growth and metastatic behavior. Perlecan possesses angiogenic and growth-promoting attributes primarily by acting as a co-receptor for basic fibroblast growth factor (FGF-2). Suppression of perlecan causes substantial inhibition of neoplastic growth and neovascularization. Thus, perlecan is a potent inducer of neoplasm growth and angiogenesis in vivo and therapeutic interventions targeting this key modulator of tumor progression may improve neoplastic treatment. Primary antibodies are available purified, or with a selection of fluorescent CF ® dyes and other labels. CF ® dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF ®405S and CF ®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.
    Aufreinigung
    Purified
    Immunogen
    Murine EHS laminin preparation
    Klon
    A7L6
    Isotyp
    IgG2a kappa
    Top Product
    Discover our top product HSPG Primärantikörper
  • Applikationshinweise
    Immunohistology formalin-fixed 1-2 μg/mL
    • Staining of formalin/paraffin tissues requires boiling tissue sections in 10 mM citrate buffer,  pH 6.0, for 10-20 min followed by cooling at RT for 20 min
    • Immunofluorescence 0.5-1 μg/mL
    • Flow Cytometry 0.5-1 μg/million cells/0.1 mL
    • Optimal dilution for a specific application should be determined by user
    Kommentare

    Breast carcinomas, squamous cell carcinomas.

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 mg/mL
    Buffer
    PBS (no BSA, no azide)
    Konservierungsmittel
    Azide free
  • Target
    HSPG (Heparan Sulphate Protoglycans (HSPG))
    Andere Bezeichnung
    Heparan Sulfate Proteoglycan (HSPG Produkte)
    Synonyme
    CDW44 antikoerper, CSPG8 antikoerper, ECMR-III antikoerper, HCELL antikoerper, HUTCH-I antikoerper, IN antikoerper, LHR antikoerper, MC56 antikoerper, MDU2 antikoerper, MDU3 antikoerper, MIC4 antikoerper, Pgp1 antikoerper, AU023126 antikoerper, AW121933 antikoerper, AW146109 antikoerper, HERMES antikoerper, Ly-24 antikoerper, Pgp-1 antikoerper, CD44A antikoerper, METAA antikoerper, RHAMM antikoerper, CD44 molecule (Indian blood group) antikoerper, glypican 3 antikoerper, CD44 antigen antikoerper, CD44 antikoerper, GPC3 antikoerper, Cd44 antikoerper
    Hintergrund
    Heparan sulfate proteoglycan of basement membrane, HSPG, Hspg2, LG3 peptide, Perlecan, PLC, SJS1
    Molekulargewicht
    >400 kDa
    Gen-ID
    3339, 562227
    UniProt
    P98160
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